Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys
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Título: | Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys |
Autor/a: | Sobrido Cameán, Daniel Robledo Sánchez, Diego Rodicio Rodicio, María Celina Barreiro Iglesias, Antón |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Bioloxía Funcional Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física |
Palabras chave: | 5-HT | Serotonin receptor 1A | cAMP | Descending neurons | Fish | Axon regeneration | CNS | |
Data: | 2019-02-20 |
Editor: | The Company of Biologists |
Cita bibliográfica: | Sobrido-Cameán, D., Robledo, D., Sánchez, L., Rodicio, M. C., & Barreiro-Iglesias, A. (2019). Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys. "Disease Models & Mechanisms", 12(2), https://doi.org/10.1242/dmm.037085 |
Resumo: | Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin in axon regeneration at the level of individually identifiable descending neurons. Pharmacological and genetic manipulations after a complete spinal cord injury showed that endogenous serotonin inhibits axonal regeneration in identifiable descending neurons through the activation of serotonin 1A receptors and a subsequent decrease in cyclic adenosine monophosphate (cAMP) levels. RNA sequencing revealed that changes in the expression of genes that control axonal guidance could be a key factor determining the serotonin effects during regeneration. This study provides new targets of interest for research in non-regenerating mammalian models of traumatic central nervous system injuries and extends the known roles of serotonin signalling during neuronal regeneration |
Versión do editor: | https://doi.org/10.1242/dmm.037085 |
URI: | http://hdl.handle.net/10347/20925 |
DOI: | 10.1242/dmm.037085 |
ISSN: | 1754-8403 |
E-ISSN: | 1754-8411 |
Dereitos: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed |
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed