Show simple item record

dc.contributor.authorSobrido Cameán, Daniel
dc.contributor.authorRobledo Sánchez, Diego
dc.contributor.authorRodicio Rodicio, María Celina
dc.contributor.authorBarreiro Iglesias, Antón
dc.date.accessioned2020-03-26T13:03:46Z
dc.date.available2020-03-26T13:03:46Z
dc.date.issued2019-02-20
dc.identifier.citationSobrido-Cameán, D., Robledo, D., Sánchez, L., Rodicio, M. C., & Barreiro-Iglesias, A. (2019). Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys. "Disease Models & Mechanisms", 12(2), https://doi.org/10.1242/dmm.037085
dc.identifier.issn1754-8403
dc.identifier.urihttp://hdl.handle.net/10347/20925
dc.description.abstractClassical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin in axon regeneration at the level of individually identifiable descending neurons. Pharmacological and genetic manipulations after a complete spinal cord injury showed that endogenous serotonin inhibits axonal regeneration in identifiable descending neurons through the activation of serotonin 1A receptors and a subsequent decrease in cyclic adenosine monophosphate (cAMP) levels. RNA sequencing revealed that changes in the expression of genes that control axonal guidance could be a key factor determining the serotonin effects during regeneration. This study provides new targets of interest for research in non-regenerating mammalian models of traumatic central nervous system injuries and extends the known roles of serotonin signalling during neuronal regeneration
dc.description.sponsorshipGrant sponsors: Spanish Ministry of Economy and Competitiveness (Ministerio de Economía, Industria y Competitividad, Gobierno de España) and the European Regional Development Fund 2007–2013 (grant numbers: BFU2014-56300-P and BFU-2017-87079-P); and Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (grant number: GPC2014/030). A.B.-I. was supported by a grant from the Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (grant number: 2016-PG008) and a grant from the crowdfunding platform Precipita (FECYT; Spanish Ministry of Economy and Competitiveness; grant number 2017-CP081)
dc.language.isoeng
dc.publisherThe Company of Biologists
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014-56300-P/ES/PAPEL DEL GABA EN LA SUPERVIVENCIA Y REGENERACION DE NEURONAS CEREBRALES DE PROYECCION ESPINAL TRAS LESION MEDULAR EN LAMPREAS
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU-2017-87079-P/ES/ EL GABA PROMUEVE LA SUPERVIVENCIA NEURONAL Y LA REGENERACION AXONAL TRAS UNA LESION MEDULAR INHIBIENDO LA VIA DE NOTCH
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.subject5-HT
dc.subjectSerotonin receptor 1A
dc.subjectcAMP
dc.subjectDescending neurons
dc.subjectFish
dc.subjectAxon regeneration
dc.subjectCNS
dc.titleSerotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1242/dmm.037085
dc.relation.publisherversionhttps://doi.org/10.1242/dmm.037085
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1754-8411
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Bioloxía Funcional
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física
dc.description.peerreviewedSI


Files in this item

application/pdf
Name: Artigo con información complementaria
Size: 12.35 Mb
Format: PDF


application/pdf
Name: Artigo sen a información complementaria
Size: 4.909 Mb
Format: PDF


Thumbnail

This item appears in the following Collection(s)

Show simple item record

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed
Except where otherwise noted, this item's license is described as  This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed





Harvesters:Useful links:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback