Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
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Title: | Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes |
Author: | Facal Mayo, David Guàrdia Olmos, Joan Pereiro Rozas, Arturo José Lojo Seoane, Cristina Peró Cebollero, Maribel Juncos Rabadán, Onésimo |
Affiliation: | Universidade de Santiago de Compostela. Departamento de Psicoloxía Evolutiva e da Educación |
Subject: | Cognitive aging | Mild cognitive impairment | Subjective cognitive complaints | Conversion to dementia | Bayesian odds ratios | Time overlapping intervals | Screening and diagnosis | |
Date of Issue: | 2019 |
Publisher: | MDPI |
Citation: | Facal, D.; Guàrdia-Olmos, J.; Pereiro, A.X.; Lojo-Seoane, C.; Peró, M.; Juncos-Rabadán, O. Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes. Brain Sci. 2019, 9, 242 |
Abstract: | (1) Background: Mild cognitive impairment (MCI) is a diagnostic label in which stability is typically low. The aim of this study was to examine temporal changes in the diagnosis of MCI subtypes by using an overlapping-time strategy; (2) Methods: The study included 435 participants aged over 50 years with subjective cognitive complaints and who completed at least one follow-up evaluation. The probability of transition was estimated using Bayesian odds ratios; (3) Results: Within the different time intervals, the controls with subjective cognitive complaints represented the largest proportion of participants, followed by sda-MCI at baseline and in the first five intervals of the follow-up, but not in the last eight intervals. The odds ratios indicated higher odds of conversion to dementia in sda-MCI and mda-MCI groups relative to na-MCI (e.g., interval 9–15 months—sda-MCI OR = 9 and mda-MCI OR = 3.36; interval 27–33—sda-MCI OR = 16 and mda-MCI = 5.06; interval 42–48—sda-MCI OR = 8.16 and mda-MCI = 3.45; interval 45–51—sda-MCI OR = 3.31 and mda-MCI = 1); (4) Conclusions: Notable patterns of instability consistent with the current literature were observed. The limitations of a prospective approach in the study of MCI transitions are discussed |
Publisher version: | https://doi.org/10.3390/brainsci9090242 |
URI: | http://hdl.handle.net/10347/21101 |
DOI: | 10.3390/brainsci9090242 |
E-ISSN: | 2076-3425 |
Rights: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) |
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Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)