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dc.contributor.authorFacal Mayo, David
dc.contributor.authorGuàrdia Olmos, Joan
dc.contributor.authorPereiro Rozas, Arturo José
dc.contributor.authorLojo Seoane, Cristina
dc.contributor.authorPeró Cebollero, Maribel
dc.contributor.authorJuncos Rabadán, Onésimo
dc.date.accessioned2020-04-02T13:45:10Z
dc.date.available2020-04-02T13:45:10Z
dc.date.issued2019
dc.identifier.citationFacal, D.; Guàrdia-Olmos, J.; Pereiro, A.X.; Lojo-Seoane, C.; Peró, M.; Juncos-Rabadán, O. Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes. Brain Sci. 2019, 9, 242
dc.identifier.urihttp://hdl.handle.net/10347/21101
dc.description.abstract(1) Background: Mild cognitive impairment (MCI) is a diagnostic label in which stability is typically low. The aim of this study was to examine temporal changes in the diagnosis of MCI subtypes by using an overlapping-time strategy; (2) Methods: The study included 435 participants aged over 50 years with subjective cognitive complaints and who completed at least one follow-up evaluation. The probability of transition was estimated using Bayesian odds ratios; (3) Results: Within the different time intervals, the controls with subjective cognitive complaints represented the largest proportion of participants, followed by sda-MCI at baseline and in the first five intervals of the follow-up, but not in the last eight intervals. The odds ratios indicated higher odds of conversion to dementia in sda-MCI and mda-MCI groups relative to na-MCI (e.g., interval 9–15 months—sda-MCI OR = 9 and mda-MCI OR = 3.36; interval 27–33—sda-MCI OR = 16 and mda-MCI = 5.06; interval 42–48—sda-MCI OR = 8.16 and mda-MCI = 3.45; interval 45–51—sda-MCI OR = 3.31 and mda-MCI = 1); (4) Conclusions: Notable patterns of instability consistent with the current literature were observed. The limitations of a prospective approach in the study of MCI transitions are discussed
dc.description.sponsorshipThis work was financially supported through FEDER founds by the Spanish Directorate General of Scientific and Technical Research (Project Ref. PSI2014-55316-C3-1-R), the National Research Agency (Spanish ’Ministry of Science, Innovation and Universities) (Project Ref. PSI2017-89389-C2-1-R) and by the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e estruturación de unidades de investigación competitivas do Sistema Universitario de Galicia; GI-1807-USC: Ref. ED431-2017/27)
dc.language.isoeng
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2014-55316-C3-1-R/ES/DETERIORO COGNITIVO EN EL ENVEJECIMIENTO NORMAL, DCL Y EA: ESTUDIO LONGITUDINAL CON MARCADORES COGNITIVOS, PSICOFISIOLOGICOS, BIOLOGICOS Y DE NEUROIMAGEN
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PSI2017-89389-C2-1-R/ES/ESTUDIO LONGITUDINAL DEL DETERIORO COGNITIVO EN EL ENVEJECIMIENTO NORMAL, DCL Y EA. EFECTOS DE UN PROGRAMA INTEGRADO DE ESTIMULACION COGNITIVA POR VIDEO-JUEGOS Y ESTIMULACION
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCognitive aging
dc.subjectMild cognitive impairment
dc.subjectSubjective cognitive complaints
dc.subjectConversion to dementia
dc.subjectBayesian odds ratios
dc.subjectTime overlapping intervals
dc.subjectScreening and diagnosis
dc.titleUsing an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/brainsci9090242
dc.relation.publisherversionhttps://doi.org/10.3390/brainsci9090242
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn2076-3425
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psicoloxía Evolutiva e da Educación
dc.description.peerreviewedSI


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's license is described as  © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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