Show simple item record

dc.contributor.authorCabana Montenegro, Sonia
dc.contributor.authorBarbosa Fernández, Silvia
dc.contributor.authorTaboada Antelo, Pablo
dc.contributor.authorConcheiro Nine, Ángel Joaquín
dc.contributor.authorÁlvarez Lorenzo, Carmen Isabel
dc.date.accessioned2020-04-06T18:44:45Z
dc.date.available2020-04-06T18:44:45Z
dc.date.issued2019
dc.identifier.citationCabana-Montenegro, S.; Barbosa, S.; Taboada, P.; Concheiro, A.; Alvarez-Lorenzo, C. Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation. Pharmaceutics 2019, 11, 52
dc.identifier.urihttp://hdl.handle.net/10347/21200
dc.description.abstractBlock copolymer dispersions that form gels at body temperature and that additionally are able to reduce a gold salt to nanoparticles (AuNPs) directly in the final formulation under mild conditions were designed as hybrid depots for photothermal therapy. The in situ gelling systems may retain AuNPs in the application zone for a long time so that localized elevations of temperature can be achieved each time the zone is irradiated. To carry out the work, dispersions were prepared covering a wide range of poloxamine Tetronic 1307:gold salt molar ratios in NaCl media (also varying from pure water to hypertonic solution). Even at copolymer concentrations well above the critical micelle concentration, the reducing power of the copolymer was maintained, and AuNPs were formed in few hours without extra additives. Varying the copolymer and NaCl concentrations allowed a fine tuning of nanoparticles’ shape from spherical to triangular nanoplates, which determined that the surface plasmon resonance showed a maximum intensity at 540 nm or at 1000 nm, respectively. The information gathered on the effects of (i) the poloxamine concentration on AuNPs’ size and shape under isotonic conditions, (ii) the AuNPs on the temperature-induced gelling transition, and (iii) the gel properties on the photothermal responsiveness of the AuNPs during successive irradiation cycles may help the rational design of one-pot gels with built-in temperature and light responsiveness.
dc.description.sponsorshipThis research was funded by MINECO (SAF2017-83118-R; MAT2016-80266-R), Agencia Estatal de Investigación (AEI) Spain, Xunta de Galicia (Grupo de Referencia Competitiva ED431C 2016/008; Agrupación Estratégica en Materiales-AEMAT ED431E 2018/08), and FEDER (Spain). S.C.-M. acknowledges a Xunta de Galicia predoctoral grant
dc.language.isoeng
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-83118-R/ES/ARQUITECTURAS POLIMERICAS 3D ACTIVAS PARA MEDICINA REGENERATIVA Y TERAPIA LOCALIZADA
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectIn situ gelling systems
dc.subjectPhoto-thermal therapy
dc.subjectGold reduction
dc.subjectLocalized heating effect
dc.subjectIrradiation cycles
dc.subjectSyringeable implant
dc.titleSyringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/pharmaceutics11020052
dc.relation.publisherversionhttps://doi.org/10.3390/pharmaceutics11020052
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1999-4923
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Física de Partículas
dc.description.peerreviewedSI


Files in this item

application/pdf
Name: 2019_pharmaceutics_cabana-montenegro-syringeable.pdf
Size: 2.086 Mb
Format: PDF


Thumbnail

This item appears in the following Collection(s)

Show simple item record

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's license is described as  © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





Harvesters:Useful links:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback