Expression of gingival crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review
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Título: | Expression of gingival crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review |
Autor/a: | Koidou, V.P. Chatzopoulos, G.S. Tomás Carmona, Inmaculada Nibali, L. Donos, Nikolaos |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas |
Palabras chave: | Gingival crevicular fluid | Markers | Guided tissue regeneration | Open flap debridement | |
Data: | 2019 |
Editor: | Springer |
Cita bibliográfica: | Koidou, V.P., Chatzopoulos, G.S., Tomas, I. et al. Expression of gingival crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review. Clin Oral Invest 24, 487–502 (2020). https://doi.org/10.1007/s00784-019-03088-4 |
Resumo: | Background: Surgical treatments such as guided tissue regeneration (GTR) and access flap surgery are widely employed for the treatment of intrabony defects. However, little is known regarding the postoperative expression of gingival crevicular fluid (GCF) markers. Objective: The aim of this systematic review was to compare the expression of GCF markers following treatment of periodontal intrabony defects with guided tissue regeneration or access surgery. The association of the markers’ expression with the clinical outcome was also assessed. Methods: An electronic literature search was conducted in MEDLINE, EMBASE, OpenGrey, LILACS and Cochrane Library up to December 2018 complemented by a manual search. Human, prospective clinical studies were identified. The changes from baseline up to 30 days (early healing) and 3 months (late healing) were assessed. Results: A total of 164 publications were identified and reviewed for eligibility. Of these, 10 publications fulfilled the inclusion criteria. The included studies evaluated 15 different GCF markers with a follow-up time between 21 and 360 days postoperatively. PDGF, VEGF and TIMP-1 changes were often investigated in the included studies; however, contrasting results were reported. Two studies agreed that both GTR and OFD lead to similar OPG level changes. TGF-β1 is increased early postoperatively, irrespective of the surgical technique employed. Conclusión: There is limited evidence available on the expression of GCF markers after surgical interventions of intrabony periodontal defects. However, OPG and TGF-β1 tend to increase early post-operatively, irrespective of the surgical technique employed, irrespective of the surgical technique employed. Clinical relevance: More well-designed, powered studies with sampling periods reflecting the regenerative process are needed, and future research should focus on employing standardised protocols for collecting, storing and analysing GCF markers |
Versión do editor: | https://doi.org/10.1007/s00784-019-03088-4 |
URI: | http://hdl.handle.net/10347/21252 |
DOI: | 10.1007/s00784-019-03088-4 |
ISSN: | 1432-6981 |
E-ISSN: | 1436-3771 |
Dereitos: | © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made |
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© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made