BDNF genetic variants and methylation: effects on cognition in major depressive disorder
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http://hdl.handle.net/10347/21276
Título: | BDNF genetic variants and methylation: effects on cognition in major depressive disorder
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Autor/a: | Ferrer, Alex
Labad, Javier
Salvat-Pujol, Neus
Barrachina, Marta
Costas Costas, Javier
Urretavizcaya, Mikel
Arriba-Arnau, Aida de
Crespo, José M.
Soriano-Mas, Carles
Carracedo Álvarez, Ángel María
Menchón, José M.
Soria, Virginia
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Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría
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Data: | 2019
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Editor: | Nature Publishing Group
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Cita bibliográfica: | Ferrer, A., Labad, J., Salvat-Pujol, N. et al. BDNF genetic variants and methylation: effects on cognition in major depressive disorder. Transl Psychiatry 9, 265 (2019). https://doi.org/10.1038/s41398-019-0601-8
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Resumo: | Brain-derived neurotrophic factor (BDNF) gene regulation has been linked to the pathophysiology of major depressive disorder (MDD). MDD patients show cognitive deficits, and altered BDNF regulation has a relevant role in neurocognitive functions. Our goal was to explore the association between BDNF genetic and epigenetic variations with neurocognitive performance in a group of MDD patients and healthy controls considering possible modulating factors. The sample included 134 subjects, 64 MDD patients, and 70 healthy controls. Clinical data, childhood maltreatment, and neurocognitive performance were assessed in all participants. Eleven single nucleotide polymorphisms (SNPs) and two promoter regions in the BDNF gene were selected for genotype and methylation analysis. The role of interactions between BDNF genetic and epigenetic variations with MDD diagnosis, sex, and Childhood Trauma Questionnaire (CTQ) scores was also explored. We observed significant associations between neurocognitive performance and two BDNF SNPs (rs908867 and rs925946), an effect that was significantly mediated by methylation values at specific promoter I sites. We identified significant associations between neurocognitive results and methylation status as well as its interactions with MDD diagnosis, sex, and CTQ scores. Our results support the hypothesis that BDNF gene SNPs and methylation status, as well as their interactions with modulating factors, can influence cognition. Further studies are required to confirm the effect of BDNF variations and cognitive function in larger samples. |
Versión do editor: | https://doi.org/10.1038/s41398-019-0601-8 |
URI: | http://hdl.handle.net/10347/21276
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DOI: | 10.1038/s41398-019-0601-8 |
E-ISSN: | 2158-3188
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Dereitos: | © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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