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dc.contributor.authorGonzález Bello, Concepción
dc.date.accessioned2020-04-10T09:28:27Z
dc.date.available2020-04-10T09:28:27Z
dc.date.issued2019
dc.identifier.citationGonzález-Bello, C. (2019). Recently developed synthetic compounds with anti-infective activity. Current Opinion In Pharmacology, 48, 17-23. doi: 10.1016/j.coph.2019.03.004
dc.identifier.issn1471-4892
dc.identifier.urihttp://hdl.handle.net/10347/21302
dc.description.abstractThe ability of antibiotics to cure bacterial infections is at a serious risk due to the emergence and worldwide spread of superbugs. A lack of innovation and investment for almost 50 years has led to significant efforts currently being devoted to find alternative and innovative therapies to face this challenge. This short review highlights some of the recent efforts to develop synthetic small molecules with anti-infective activity. This article is focused on those compounds that, when co-administered with an antibiotic, enhance the antimicrobial action of the drug, as well as compounds that target unexplored objectives for bacterial survival. Selected examples are provided.
dc.description.sponsorshipFinancial support from the Spanish Ministry of Economy andCompetiveness (SAF2016-75638-R), the Xunta de Galicia [Centro Singularde Investigación de Galicia accreditation 2016–2019 (ED431G/09) andED431B 2018/04] and the European Union (European RegionalDevelopment Fund – ERDF is gratefully acknowledged
dc.language.isoeng
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-75638-R/ES
dc.rights© 2019 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAntibiotics
dc.subjectBacterium
dc.subjectSuperbugs
dc.titleRecently developed synthetic compounds with anti-infective activity
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1016/j.coph.2019.03.004
dc.relation.publisherversionhttps://doi.org/10.1016/j.coph.2019.03.004
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1471-4973
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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© 2019 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as  © 2019 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).





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