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dc.contributor.author | González Bello, Concepción |
dc.date.accessioned | 2020-04-10T09:28:27Z |
dc.date.available | 2020-04-10T09:28:27Z |
dc.date.issued | 2019 |
dc.identifier.citation | González-Bello, C. (2019). Recently developed synthetic compounds with anti-infective activity. Current Opinion In Pharmacology, 48, 17-23. doi: 10.1016/j.coph.2019.03.004 |
dc.identifier.issn | 1471-4892 |
dc.identifier.uri | http://hdl.handle.net/10347/21302 |
dc.description.abstract | The ability of antibiotics to cure bacterial infections is at a serious risk due to the emergence and worldwide spread of superbugs. A lack of innovation and investment for almost 50 years has led to significant efforts currently being devoted to find alternative and innovative therapies to face this challenge. This short review highlights some of the recent efforts to develop synthetic small molecules with anti-infective activity. This article is focused on those compounds that, when co-administered with an antibiotic, enhance the antimicrobial action of the drug, as well as compounds that target unexplored objectives for bacterial survival. Selected examples are provided. |
dc.description.sponsorship | Financial support from the Spanish Ministry of Economy andCompetiveness (SAF2016-75638-R), the Xunta de Galicia [Centro Singularde Investigación de Galicia accreditation 2016–2019 (ED431G/09) andED431B 2018/04] and the European Union (European RegionalDevelopment Fund – ERDF is gratefully acknowledged |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.rights | © 2019 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject | Antibiotics |
dc.subject | Bacterium |
dc.subject | Superbugs |
dc.title | Recently developed synthetic compounds with anti-infective activity |
dc.type | journal article |
dc.identifier.doi | 10.1016/j.coph.2019.03.004 |
dc.relation.publisherversion | https://doi.org/10.1016/j.coph.2019.03.004 |
dc.type.hasVersion | VoR |
dc.identifier.essn | 1471-4973 |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
dc.description.peerreviewed | SI |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-75638-R/ES |
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