Chain-branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/21304
Ficheiros no ítem
Metadatos do ítem
Título: | Chain-branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases |
Autor/a: | Estévez Cabanas, Juan Carlos González, Marcos A. Villaverde Cameron-Walker, María del Carmen Hirokami, Yuki Kato, Atsushi Sussman, Fredy Salomon Reza Ramos, David Estévez Cabanas, Ramón José |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Palabras chave: | Sugars | Iminosugars | Glycosidase inhibition | |
Data: | 2019 |
Editor: | MDPI |
Cita bibliográfica: | Estévez, J.C.; González, M.A.; Villaverde, M.C.; Hirokami, Y.; Kato, A.; Sussman, F.; Reza, D.; Estévez, R.J. Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases. Pharmaceuticals 2019, 12, 47 |
Resumo: | Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed by a protocol involving the formation of the azacyclopentane ring. Results of inhibitory potency assays and docking calculations show that at least one of them could be a lead for optimization in the search for compounds that behave like folding chaperones in lysosomal storage diseases |
Versión do editor: | https://doi.org/10.3390/ph12020047 |
URI: | http://hdl.handle.net/10347/21304 |
DOI: | 10.3390/ph12020047 |
E-ISSN: | 1424-8247 |
Dereitos: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) |
Coleccións
-
- CIQUS-Artigos [475]
- QO-Artigos [436]