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dc.contributor.authorLuzardo Álvarez, Asteria María
dc.contributor.authorLamela Gómez, Iván
dc.contributor.authorOtero Espinar, Francisco Javier
dc.contributor.authorBlanco Méndez, José
dc.date.accessioned2020-04-13T05:48:37Z
dc.date.available2020-04-13T05:48:37Z
dc.date.issued2019
dc.identifier.citationLuzardo-Álvarez, A.; Lamela-Gómez, I.; Otero-Espinar, F.; Blanco-Méndez, J. Development, Characterization, and In Vitro Evaluation of Resveratrol-Loaded Poly-(ε-caprolactone) Microcapsules Prepared by Ultrasonic Atomization for Intra-Articular Administration. Pharmaceutics 2019, 11, 249
dc.identifier.urihttp://hdl.handle.net/10347/21312
dc.description.abstractIntra-articular administration of drugs to the joint in the treatment of joint disease has the potential to minimize the systemic bioavailability and the usual side-effects associated with oral drug administration. In this work, a drug delivery system is proposed to achieve an anti-inflammatory local effect using resveratrol (RSV). This study aims to develop microcapsules made of poly-(ε-caprolactone) (PCL) by ultrasonic atomization to preserve the antioxidant activity of RSV, to prevent its degradation and to suppress the inflammatory response in activated RAW 264.7 macrophages. An experimental design was performed to build a mathematical model that could estimate the effect of nozzle power and polymer concentration on particle size and encapsulation efficiency. RSV-loaded microcapsules showed adequate morphology, particle size, and loading efficiency properties. RSV formulations exhibited negligible cytotoxicity and an efficient amelioration of inflammatory responses, in terms of Nitric Oxide (NO), ROS (Reactive Oxygen Species), and lipid peroxidation in macrophages. Thus, RSV-loaded microcapsules merit consideration as a drug delivery system suitable for intra-articular administration in inflammatory disorders affecting the joint
dc.description.sponsorshipAcknowledgments: I.L.-G. is grateful to “Programa de axudas á etapa predoutoral da Xunta de Galicia (cofinanciadas por FSE Galicia 2014-2020), Consellería de Cultura, Educación e Ordenación Universitaria” program for doctoral fellowship
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDrug delivery system
dc.subjectMicrocapsules
dc.subjectPhotodegradation
dc.subjectUltrasound
dc.subjectAntioxidant
dc.subjectSite-specific delivery
dc.subjectResveratrol
dc.titleDevelopment, Characterization, and In Vitro Evaluation of Resveratrol-Loaded Poly-(ε-caprolactone) Microcapsules Prepared by Ultrasonic Atomization for Intra-Articular Administration
dc.typejournal article
dc.identifier.doi10.3390/pharmaceutics11060249
dc.relation.publisherversionhttps://doi.org/10.3390/pharmaceutics11060249
dc.type.hasVersionVoR
dc.identifier.essn1999-4923
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.description.peerreviewedSI


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
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 © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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