Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function
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Título: | Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function |
Autor/a: | Ramos, Adriana Rodríguez Seoane, Carmen Rosa, Isaac Gorroño Etxebarria, Irantzu Alonso Lorenzo, Jana Veiga Sans, Sonia Korth, Carsten Kypta, Robert M. García Alonso, Ángel Rodríguez Requena, Jesús |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina |
Palabras chave: | DISC1 | Neurodevelopment | Synapse | CRMP-2 | Proteomics | |
Data: | 2019 |
Editor: | MDPI |
Cita bibliográfica: | Ramos, A.; Rodríguez-Seoane, C.; Rosa, I.; Gorroño-Etxebarria, I.; Alonso, J.; Veiga, S.; Korth, C.; Kypta, R.M.; García, Á.; Requena, J.R. Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function. Int. J. Mol. Sci. 2019, 20, 119. |
Resumo: | A balanced chromosomal translocation disrupting DISC1 (Disrupted in Schizophrenia 1) gene has been linked to psychiatric diseases, such as major depression, bipolar disorder and schizophrenia. Since the discovery of this translocation, many studies have focused on understating the role of the truncated isoform of DISC1, hypothesizing that the gain of function of this protein could be behind the neurobiology of mental conditions, but not so many studies have focused in the mechanisms impaired due to its loss of function. For that reason, we performed an analysis on the cellular proteome of primary neurons in which DISC1 was knocked down with the goal of identifying relevant pathways directly affected by DISC1 loss of function. Using an unbiased proteomic approach, we found that the expression of 31 proteins related to neurodevelopment (e.g., CRMP-2, stathmin) and synaptic function (e.g., MUNC-18, NCS-1) is altered by DISC1 in primary mouse neurons. Hence, this study reinforces the idea that DISC1 is a unifying regulator of both neurodevelopment and synaptic function, thereby providing a link between these two key anatomical and cellular circuitries. |
Versión do editor: | https://doi.org/10.3390/ijms20010119 |
URI: | http://hdl.handle.net/10347/21323 |
DOI: | 10.3390/ijms20010119 |
E-ISSN: | 1422-0067 |
Dereitos: | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) |
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