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dc.contributor.authorRamos, Adriana
dc.contributor.authorRodríguez Seoane, Carmen
dc.contributor.authorRosa, Isaac
dc.contributor.authorGorroño Etxebarria, Irantzu
dc.contributor.authorAlonso Lorenzo, Jana
dc.contributor.authorVeiga Sans, Sonia
dc.contributor.authorKorth, Carsten
dc.contributor.authorKypta, Robert M.
dc.contributor.authorGarcía Alonso, Ángel
dc.contributor.authorRodríguez Requena, Jesús
dc.date.accessioned2020-04-13T15:33:18Z
dc.date.available2020-04-13T15:33:18Z
dc.date.issued2019
dc.identifier.citationRamos, A.; Rodríguez-Seoane, C.; Rosa, I.; Gorroño-Etxebarria, I.; Alonso, J.; Veiga, S.; Korth, C.; Kypta, R.M.; García, Á.; Requena, J.R. Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function. Int. J. Mol. Sci. 2019, 20, 119.
dc.identifier.urihttp://hdl.handle.net/10347/21323
dc.description.abstractA balanced chromosomal translocation disrupting DISC1 (Disrupted in Schizophrenia 1) gene has been linked to psychiatric diseases, such as major depression, bipolar disorder and schizophrenia. Since the discovery of this translocation, many studies have focused on understating the role of the truncated isoform of DISC1, hypothesizing that the gain of function of this protein could be behind the neurobiology of mental conditions, but not so many studies have focused in the mechanisms impaired due to its loss of function. For that reason, we performed an analysis on the cellular proteome of primary neurons in which DISC1 was knocked down with the goal of identifying relevant pathways directly affected by DISC1 loss of function. Using an unbiased proteomic approach, we found that the expression of 31 proteins related to neurodevelopment (e.g., CRMP-2, stathmin) and synaptic function (e.g., MUNC-18, NCS-1) is altered by DISC1 in primary mouse neurons. Hence, this study reinforces the idea that DISC1 is a unifying regulator of both neurodevelopment and synaptic function, thereby providing a link between these two key anatomical and cellular circuitries.
dc.description.sponsorshipThis research was funded by ERANET-NEURON, grant DISCover (National funding institution grants: ISCIII PI09/2688 and BMBF 01EW1003, respectively, to J.R.R. and C.K.), and grants from the DFG (Ko1679/3-1), NARSAD 2013 Independent Investigator Award #20350 and EU-FP MC-ITN "IN-SENS" #607616) (C.K.); The Spanish Ministry of Science and Innovation (SAF2011-30494 and BFU2017-86692-P, partially funded by European Union regional funds (FRDER)); the Departments of Industry, Tourism and Trade (Etortek) and Innovation Technology of the Government of the Autonomous Community of the Basque Country (R.M.K. and I.G-E.); and the Spanish Ministry of Economy and Competitiveness (SAF2013-45014-R, A.G., SAF2011-30494 (R.M.K. and I.G-E.))
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDISC1
dc.subjectNeurodevelopment
dc.subjectSynapse
dc.subjectCRMP-2
dc.subjectProteomics
dc.titleProteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function
dc.typejournal article
dc.identifier.doi10.3390/ijms20010119
dc.relation.publisherversionhttps://doi.org/10.3390/ijms20010119
dc.type.hasVersionVoR
dc.identifier.essn1422-0067
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina
dc.description.peerreviewedSI


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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
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 © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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