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dc.contributor.authorRobles Martínez, Pamela
dc.contributor.authorXu, Xiaoyan
dc.contributor.authorTrenfield, Sarah J.
dc.contributor.authorAwad, Atheer
dc.contributor.authorGoyanes Goyanes, Álvaro
dc.contributor.authorTelford, Richard
dc.contributor.authorBasit, Abdul W.
dc.contributor.authorGaisford, Simon
dc.date.accessioned2020-04-13T20:57:00Z
dc.date.available2020-04-13T20:57:00Z
dc.date.issued2019
dc.identifier.citationRobles-Martinez, P.; Xu, X.; Trenfield, S.J.; Awad, A.; Goyanes, A.; Telford, R.; Basit, A.W.; Gaisford, S. 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method. Pharmaceutics 2019, 11, 274
dc.identifier.urihttp://hdl.handle.net/10347/21335
dc.description.abstractThree-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamol, caffeine, naproxen, chloramphenicol, prednisolone and aspirin, were printed with different geometries and material compositions. Drug distribution was visualised using Raman microscopy, which showed that whilst separate layers were successfully printed, several of the drugs diffused across the layers depending on their amorphous or crystalline phase. The printed constructs demonstrated excellent physical properties and the different material inclusions enabled distinct drug release profiles of the six actives within dissolution tests. For the first time, this paper demonstrates the feasibility of SLA printing as an innovative platform for multi-drug therapy production, facilitating a new era of personalised polypills
dc.description.sponsorshipThe authors thank the Engineering and Physical Sciences Research Council (EPSRC), UK for their financial support (EP/L01646X)
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectThree-dimensional printing
dc.subjectAdditive manufacturing
dc.subjectPrintlets
dc.subjectTablets
dc.subjectPersonalized medicines
dc.subjectMultiple-layer dosage forms
dc.subjectStereolithography
dc.subjectVat polymerisation
dc.title3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/pharmaceutics11060274
dc.relation.publisherversionhttps://doi.org/10.3390/pharmaceutics11060274
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1999-4923
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.description.peerreviewedSI


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's license is described as  © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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