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dc.contributor.authorCadete, Ana
dc.contributor.authorOlivera, Ana
dc.contributor.authorBesev, Magnus
dc.contributor.authorDhal, Pradeep
dc.contributor.authorGonçalves, Lídia
dc.contributor.authorAlmeida, António J.
dc.contributor.authorBastiat, Guillaume
dc.contributor.authorBenoit, Jean-Pierre
dc.contributor.authorFuente, María de la
dc.contributor.authorGarcía Fuentes, Marcos
dc.contributor.authorAlonso Fernández, María José
dc.contributor.authorTorres López, María Dolores Ramona
dc.date.accessioned2020-04-13T21:40:13Z
dc.date.available2020-04-13T21:40:13Z
dc.date.issued2019
dc.identifier.citationCadete, A., Olivera, A., Besev, M. et al. Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs. Sci Rep 9, 11565 (2019). https://doi.org/10.1038/s41598-019-47995-8
dc.identifier.urihttp://hdl.handle.net/10347/21340
dc.description.abstractPreparation of sophisticated delivery systems for nanomedicine applications generally involve multi-step procedures using organic solvents. In this study, we have developed a simple self-assembling process to prepare docetaxel-loaded hyaluronic acid (HA) nanocapsules by using a self-emulsification process without the need of organic solvents, heat or high shear forces. These nanocapsules, which comprise an oily core and a shell consisting of an assembly of surfactants and hydrophobically modified HA, have a mean size of 130 nm, a zeta potential of −20 mV, and exhibit high docetaxel encapsulation efficiency. The nanocapsules exhibited an adequate stability in plasma. Furthermore, in vitro studies performed using A549 lung cancer cells, showed effective intracellular delivery of docetaxel. On the other hand, blank nanocapsules showed very low cytotoxicity. Overall, these results highlight the potential of self-emulsifying HA nanocapsules for intracellular drug delivery.
dc.description.sponsorshipThe authors acknowledge financial support from Xunta de Galicia (Competitive Reference Groups-FEDER Funds GRC2013-043). A. Cadete acknowledges her doctoral fellowship from the European Commission (EACEA) under the Nanofar program, Erasmus Mundus Joint Doctorate (EMJD). A. Olivera acknowledges her doctoral fellowship from the Spanish Ministry of Science, Innovation and Universities (grant number BES-2015-071236)
dc.language.isoeng
dc.publisherNature Publishing Group
dc.rights© The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCell delivery
dc.subjectChemical modification
dc.subjectDrug delivery
dc.subjectNanoparticles
dc.titleSelf-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1038/s41598-019-47995-8
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-019-47995-8
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn2045-2322
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.description.peerreviewedSI


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© The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as  © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/





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