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dc.contributor.authorVargas Osorio, Zulema
dc.contributor.authorLuzardo Álvarez, Asteria María
dc.contributor.authorPiñeiro Redondo, Yolanda
dc.contributor.authorVázquez Vázquez, Carlos
dc.contributor.authorGómez Amoza, José Luis
dc.contributor.authorBlanco Méndez, José
dc.contributor.authorOtero Espinar, Francisco Javier
dc.contributor.authorRivas Rey, José
dc.identifier.citationVargas-Osorio, Z., Luzardo-Álvarez, A., Piñeiro, Y., Vázquez-Vázquez, C., Gómez-Amoza, J.L., Blanco-Méndez, J., Otero Espinar, F.J., Rivas, J. (2019) Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility. "ACS Omega", 4 (3), 5496-5508
dc.description.abstractThe development of scaffolds with suitable physicochemical and mechanical properties allowing for the structural regeneration of injured bone and recovery of the natural biological functionality is still a challenge in the tissue engineering field. Nanostructured materials with added theranostic abilities, together with an interconnected hierarchy of pores, offer the possibility to provide a new generation of bone implants. In this work, scaffolds with highly porous and resistant threedimensional structures have been successfully developed by homogeneously embedding mesoporous silica nanostructures in a bioactive matrix of chitosan/κ-carrageenan. Moreover, magnetite (Fe3O4) nanoparticles were also added to the mesoporous scaffold to include additional magnetic functionalities for diagnostic or therapeutic actions. The complete physicochemical characterization shows mesoporous materials with a wide range of interconnected pores, remarkable surface roughness, and large effective surface area, suitable for cell adhesion. In accordance to these properties, a simvastatin loading and release assay showed high loading capacities and sustained release over a long period of time. Together with a suitable resistance against degradation and biocompatible performance assessed by cell viability assays, these scaffolds show interesting features for delivering drugs with activity in bone regeneration processes.
dc.description.sponsorshipThis work was supported by the European Commission (PANA project, Call H2020-NMP-2015-two-stage, grant 686009); and the Xunta de Galicia (GPC2017/015), and partially supported by the Consellería de Educacion Program ́ for the Development of Strategic Grouping in Materials AEMAT at the University of Santiago de Compostela under grant no. ED431E2018/08, Xunta de Galicia and Program for the Consolidation of Research Units of Competitive Reference GRC2017, grant no. ED431C 2017/22
dc.publisherAmerican Chemical Society
dc.rightsCopyright © 2019 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes
dc.titleThree-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Física Aplicada
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Física

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