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dc.contributor.authorDocampo Seara, Alberto
dc.contributor.authorSantos Durán, Gabriel Nicolás
dc.contributor.authorCandal Suárez, Eva María
dc.contributor.authorRodríguez Díaz, Miguel Ángel
dc.date.accessioned2020-04-15T09:06:32Z
dc.date.available2020-04-15T09:06:32Z
dc.date.issued2019
dc.identifier.citationDocampo-Seara, A., Santos-Durán, G.N., Candal, E. et al. Expression of radial glial markers (GFAP, BLBP and GS) during telencephalic development in the catshark (Scyliorhinus canicula). Brain Struct Funct 224, 33–56 (2019). https://doi.org/10.1007/s00429-018-1758-2
dc.identifier.issn1863-2653
dc.identifier.urihttp://hdl.handle.net/10347/21409
dc.description.abstractRadial glial cells (RGCs) are the first cell populations of glial nature to appear during brain ontogeny. They act as primary progenitor (stem) cells as well as a scaffold for neuronal migration. The proliferative capacity of these cells, both in development and in adulthood, has been subject of interest during past decades. In contrast with mammals where RGCs are restricted to specific ventricular areas in the adult brain, RGCs are the predominant glial element in fishes. However, developmental studies on the RGCs of cartilaginous fishes are scant. We have studied the expression patterns of RGCs markers including glial fibrillary acidic protein (GFAP), brain lipid binding protein (BLBP), and glutamine synthase (GS) in the telencephalic hemispheres of catshark (Scyliorhinus canicula) from early embryos to post-hatch juveniles. GFAP, BLBP and GS are first detected, respectively, in early, intermediate and late embryos. Expression of these glial markers was observed in cells with radial glia morphology lining the telencephalic ventricles, as well as in their radial processes and endfeet at the pial surface and their expression continue in ependymal cells (or tanycytes) in early juveniles. In addition, BLBP- and GS-immunoreactive cells morphologically resembling oligodendrocytes were observed. In late embryos, most of the GFAP- and BLBP-positive RGCs also coexpress GS and show proliferative activity. Our results indicate the existence of different proliferating subpopulations of RGCs in the embryonic ventricular zone of catshark. Further investigations are needed to determine whether these proliferative RGCs could act as neurogenic and/or gliogenic precursors.
dc.description.sponsorshipThis work was supported by the Spanish Ministerio de Economía y Competitividad-FEDER (BFU2014-5863-1P); Xunta de Galicia-FEDER, Grant number: Rede Galega INBIOEST ED341D R2016/032
dc.language.isoeng
dc.publisherSpringer
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014-5863-1-P/ES
dc.rights© The Author(s) 2018. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativeco mmons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectRadial glia
dc.subjectOligodendrocytes
dc.subjectProliferation
dc.subjectDevelopment
dc.subjectGFAP
dc.subjectBLBP
dc.subjectGS
dc.titleExpression of radial glial markers (GFAP, BLBP and GS) during telencephalic development in the catshark (Scyliorhinus canicula)
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1007/s00429-018-1758-2
dc.relation.publisherversionhttps://doi.org/10.1007/s00429-018-1758-2
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1863-2661
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Bioloxía Funcional
dc.description.peerreviewedSI


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© The Author(s) 2018. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativeco mmons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
Except where otherwise noted, this item's license is described as  © The Author(s) 2018. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativeco mmons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made





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