A bio-inspired hypoxia sensor using HIF1a-oxygen-dependent degradation domain
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| Title: | A bio-inspired hypoxia sensor using HIF1a-oxygen-dependent degradation domain |
| Author: | Iglesias, Pablo Penas Tallón, Cristina Barral Cagiao, Laura Pazos Chantrero, Elena Costoya Puente, José Antonio |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Fisioloxía Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Subject: | Chemical biology | Cancer | |
| Date of Issue: | 2019 |
| Publisher: | Nature Publishing Group |
| Citation: | Iglesias, P., Penas, C., Barral-Cagiao, L. et al. (2019). A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain. Sci Rep 9, 7117. doi:10.1038/s41598-019-43618-4 |
| Abstract: | Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. One of the characteristic features of some tumour types is that their fast growth leads to defcient intratumoral vascularization, which results in low oxygen availability. To overcome this lack of oxygen, tumoural cells activate the neoangiogenic program by upregulating the transcription factor HIF-1α. Herein we report a non-invasive in vitro detection method of hypoxia using designed fuorescent peptide probes based on the oxygen-dependent degradation domain of HIF-1α. The fuorescent probe retains the oxygen-sensing capability of HIF-1α, so that it is stabilized under hypoxia and readily degraded by the proteasome under normoxia, thus providing direct information of the cellular oxygen availability |
| Publisher version: | https://doi.org/10.1038/s41598-019-43618-4 |
| URI: | http://hdl.handle.net/10347/21556 |
| DOI: | 10.1038/s41598-019-43618-4 |
| E-ISSN: | 2045-2322 |
| Rights: | © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
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Except where otherwise noted, this item's license is described as © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/