Mostrar o rexistro simple do ítem

dc.contributor.authorJohann, Kornelia
dc.contributor.authorCremer, Anna Lena
dc.contributor.authorFischer, Alexander W.
dc.contributor.authorHeine, Markus
dc.contributor.authorRial Pensado, Eva
dc.contributor.authorResch, Julia
dc.contributor.authorNock, Sebastian
dc.contributor.authorVirtue, Samuel
dc.contributor.authorHarder, Lisbeth
dc.contributor.authorOelkrug, Rebecca
dc.contributor.authorAstiz, Mariana
dc.contributor.authorBrabant, Georg
dc.contributor.authorWarner, Amy
dc.contributor.authorVidal Puig, Antonio
dc.contributor.authorOster, Henrik
dc.contributor.authorBoelen, Anita
dc.contributor.authorLópez Pérez, Miguel Antonio
dc.contributor.authorHeeren, Joerg
dc.contributor.authorDalley, Jeffrey W.
dc.contributor.authorBackes, Heiko
dc.contributor.authorMittag, Jens
dc.date.accessioned2020-04-22T12:55:35Z
dc.date.available2020-04-22T12:55:35Z
dc.date.issued2019
dc.identifier.citationJohann, K., Cremer, A. L., Fischer, A.W. et al. (2019). Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. Cell rep, 27, 11, 3385-3400. doi: 10.1016/j.celrep.2019.05.054
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/10347/21643
dc.description.abstractRegulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and potentially providing metabolic benefits. Here, we show that browning by TH requires TH-receptor β and occurs independently of the sympathetic nervous system. The beige fat, however, lacks sufficient adrenergic stimulation and is not metabolically activated despite high levels of uncoupling protein 1 (UCP1). Studies at different environmental temperatures reveal that TH instead causes hyperthermia by actions in skeletal muscle combined with a central body temperature set-point elevation. Consequently, the metabolic and thermogenic effects of systemic hyperthyroidism were maintained in UCP1 knockout mice, demonstrating that neither beige nor brown fat contributes to the TH-induced hyperthermia and elevated glucose consumption, and underlining that the mere presence of UCP1 is insufficient to draw conclusions on the therapeutic potential of browning agents
dc.description.sponsorshipThis work was supported by grants of the Deutsche Forschungsgemeinschaft (MI1242/2-2 and 3-2 Heisenberg Program and MI1242/4-1 and 5-1 SPP1629 “Thyroid TransAct” to J.M.; AS547-1/1 to M.A.; GRK1957 “Adipocyte-Brain-Crosstalk”), Young Active Research in Endocrinology, Bioscientifica Trust (BT-000011), and European Society for Endocrinology to K.J. A.V.-P. and S.V. were funded by the BHF (RG/18/7/33636). M.L. was funded by Xunta de Galicia (2016-PG068) and Ministerio de Economía y Competitividad (MINECO) (SAF2015-71026-R). H.O. is a Lichtenberg Fellow of the Volkswagen Stiftung
dc.language.isoeng
dc.publisherElsevier
dc.rights© 2019 The Author(s). Open Access. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. To request permission for a type of use not listed, please contact Elsevier Global Rights Department
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBrown adipose tissue
dc.subjectBeige adipose tissue
dc.subjectUncoupling protein 1
dc.subjectThyroid hormone receptor
dc.subjectBody temperature
dc.subjectNorepinephrine
dc.subjectSympathetic nervous system
dc.subjectMetabolism
dc.subjectBeta3-adrenergic receptor
dc.subjectPyrexia
dc.subjectHyperthermia
dc.subjectGlucose tolerance
dc.titleThyroid-hormone-induced browning of white adipose tissue does not contribute to thermogenesis and glucose consumption
dc.typejournal article
dc.identifier.doi10.1016/j.celrep.2019.05.054
dc.type.hasVersionVoR
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxía
dc.description.peerreviewedSI


Ficheiros no ítem

application/pdf
Nome: 2019_cellrep_Johann_thyroid.pdf
Tamaño: 6.003 Mb
Formato: PDF


Thumbnail

Este ítem aparece na(s) seguinte(s) colección(s)

Mostrar o rexistro simple do ítem

© 2019 The Author(s). Open Access. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. To request permission for a type of use not listed, please contact Elsevier Global Rights Department
A licenza do ítem descríbese como
 © 2019 The Author(s). Open Access. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. To request permission for a type of use not listed, please contact Elsevier Global Rights Department





Recolectores:Enlaces de interese:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contacto | Suxestións