Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin
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Title: | Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin |
Author: | López Iglesias, Clara Barros, Joana Ardao Palacios, Inés Gurikov, Pavel Monteiro, Fernando J. Smirnova, Irina Álvarez Lorenzo, Carmen Isabel García González, Carlos Alberto |
Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
Subject: | Biopolymers | Polymer Processing | Biomedical Applications | Wound Treatment | Chitosan | Aerogels | |
Date of Issue: | 2020 |
Publisher: | MDPI |
Citation: | López-Iglesias, C.; Barros, J.; Ardao, I.; Gurikov, P.; Monteiro, F.J.; Smirnova, I.; Alvarez-Lorenzo, C.; García-González, C.A. Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin. Polymers 2020, 12, 273. |
Abstract: | Biopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based aerogels in the form of microparticles are of special interest for wound treatment and can also be loaded with bioactive agents to improve the healing process. However, the production of the precursor gel may be limited by the viscosity of the polysaccharide initial solution. The jet cutting technique is regarded as a suitable processing technique to overcome this problem. In this work, the technological combination of jet cutting and supercritical drying of gels was assessed to produce chitosan aerogel microparticles loaded with vancomycin HCl (antimicrobial agent) for wound healing purposes. The resulting aerogel formulation was evaluated in terms of morphology, textural properties, drug loading, and release profile. Aerogels were also tested for wound application in terms of exudate sorption capacity, antimicrobial activity, hemocompatibility, and cytocompatibility. Overall, the microparticles had excellent textural properties, absorbed high amounts of exudate, and controlled the release of vancomycin HCl, providing sustained antimicrobial activity. |
Publisher version: | https://doi.org/10.3390/polym12020273 |
URI: | http://hdl.handle.net/10347/21688 |
DOI: | 10.3390/polym12020273 |
E-ISSN: | 2073-4360 |
Rights: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) |
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