Cell senescence contributes to tissue regeneration in zebrafish
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/21781
Ficheiros no ítem
Metadatos do ítem
Título: | Cell senescence contributes to tissue regeneration in zebrafish |
Autor/a: | Silva Álvarez, Sabela da Guerra Varela, Jorge Sobrido Cameán, Daniel Quelle Regaldie, Ana Barreiro Iglesias, Antón Sánchez Piñón, Laura Elena Collado, Manuel |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Bioloxía Funcional Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física |
Palabras chave: | Cellular Senescence | Regeneration | Tissue Injury | Zebrafish | |
Data: | 2020 |
Editor: | Wiley |
Cita bibliográfica: | Da Silva‐Álvarez, S, Guerra‐Varela, J, Sobrido‐Cameán, D, et al. Cell senescence contributes to tissue regeneration in zebrafish. Aging Cell. 2020; 19:e13052. https://doi.org/10.1111/acel.13052 |
Resumo: | Cellular senescence is a stress response that limits the proliferation of damaged cells by establishing a permanent cell cycle arrest. Different stimuli can trigger senescence but excessive production or impaired clearance of these cells can lead to their accumulation during aging with deleterious effects. Despite this potential negative side of cell senescence, its physiological role as a pro‐regenerative and morphogenetic force has emerged recently after the identification of programmed cell senescence during embryogenesis and during wound healing and limb regeneration. Here, we explored the conservation of tissue injury‐induced senescence in a model of complex regeneration, the zebrafish. Fin amputation in adult fish led to the appearance of senescent cells at the site of damage, and their removal impaired tissue regeneration. Despite many conceptual similarities, this tissue repair response is different from developmental senescence. Our results lend support to the notion that cell senescence is a positive response promoting tissue repair and homeostasis. |
Versión do editor: | https://doi.org/10.1111/acel.13052 |
URI: | http://hdl.handle.net/10347/21781 |
DOI: | 10.1111/acel.13052 |
ISSN: | 1474-9718 |
E-ISSN: | 1474-9726 |
Dereitos: | © 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited |
Coleccións
-
- BCE-Artigos [130]
- ZAF-Artigos [273]
A licenza do ítem descríbese como
© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited