Parabrachial Interleukin-6 reduces body weight and food intake and increases thermogenesis to regulate energy metabolism
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|Title:||Parabrachial Interleukin-6 reduces body weight and food intake and increases thermogenesis to regulate energy metabolism
Richard, Jennifer E.
Porteiro Couto, Begoña
López Ferreras, Lorena
Shevchouk, Olesya T.
Olofsson, Charlotta S.
Wernstedt Asterholm, Ingrid
Grill, Harvey J.
Nogueiras Pozo, Rubén
Skibicka, Karolina P.
|Affiliation:||Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas
Universidade de Santiago de Compostela. Departamento de Fisioloxía
|Subject:||Lateral PBN | Hindbrain | Energy balance | Cold exposure | Obesity | Thyroid | Brown adipose tissue | Diet-induced obesity | Sex differences | PVN ||
|Date of Issue:||2019
|Citation:||Mishra et al. (2019). Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism. Cell Reports 26, 3011–3026. doi: 10.1016/j.celrep.2019.02.044
|Abstract:||Chronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, the mechanisms by which it controls energy balance and its role in obesity remain unclear. Here, we show that brain-produced IL-6 is decreased in obese mice and rats in a neuroanatomically and sex-specific manner. Reduced IL-6 mRNA localized to lateral parabrachial nucleus (lPBN) astrocytes, microglia, and neurons, including paraventricular hypothalamus-innervating lPBN neurons. IL-6 microinjection into lPBN reduced food intake and increased brown adipose tissue (BAT) thermogenesis in male lean and obese rats by increasing thyroid and sympathetic outflow to BAT. Parabrachial IL-6 interacted with leptin to reduce feeding. siRNA-mediated reduction of lPBN IL-6 leads to increased weight gain and adiposity, reduced BAT thermogenesis, and increased food intake. Ambient cold exposure partly normalizes the obesity-induced suppression of lPBN IL-6. These results indicate that lPBN-produced IL-6 regulates feeding and metabolism and pinpoints (patho)physiological contexts interacting with lPBN IL-6|
|Rights:||© 2019 The Author(s). Open Access. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed
Except where otherwise noted, this item's license is described as © 2019 The Author(s). Open Access. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed