Mitogenomes from the 1000 genome project reveal new Near Eastern features in present-day Tuscans
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Título: | Mitogenomes from the 1000 genome project reveal new Near Eastern features in present-day Tuscans |
Autor/a: | Gómez Carballa, Alberto Pardo Seco, Jacobo José Amigo Lechuga, Jorge Martinón Torres, Federico Salas Ellacuriaga, Antonio |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría |
Data: | 2015 |
Editor: | PLOS |
Cita bibliográfica: | Gómez-Carballa A, Pardo-Seco J, Amigo J, Martinón-Torres F, Salas A (2015) Mitogenomes from The 1000 Genome Project Reveal New Near Eastern Features in Present-Day Tuscans. PLoS ONE 10(3): e0119242. https://doi.org/10.1371/journal.pone.0119242 |
Resumo: | Background Genetic analyses have recently been carried out on present-day Tuscans (Central Italy) in order to investigate their presumable recent Near East ancestry in connection with the long-standing debate on the origins of the Etruscan civilization. We retrieved mitogenomes and genome-wide SNP data from 110 Tuscans analyzed within the context of The 1000 Genome Project. For phylogeographic and evolutionary analysis we made use of a large worldwide database of entire mitogenomes (>26,000) and partial control region sequences (>180,000). Results Different analyses reveal the presence of typical Near East haplotypes in Tuscans representing isolated members of various mtDNA phylogenetic branches. As a whole, the Near East component in Tuscan mitogenomes can be estimated at about 8%; a proportion that is comparable to previous estimates but significantly lower than admixture estimates obtained from autosomal SNP data (21%). Phylogeographic and evolutionary inter-population comparisons indicate that the main signal of Near Eastern Tuscan mitogenomes comes from Iran. Conclusions Mitogenomes of recent Near East origin in present-day Tuscans do not show local or regional variation. This points to a demographic scenario that is compatible with a recent arrival of Near Easterners to this region in Italy with no founder events or bottlenecks. |
Versión do editor: | https://doi.org/10.1371/journal.pone.0119242 |
URI: | http://hdl.handle.net/10347/21896 |
DOI: | 10.1371/journal.pone.0119242 |
E-ISSN: | 1932-6203 |
Dereitos: | © 2015 Gómez-Carballa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
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