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dc.contributor.authorBarbosa, Mario
dc.contributor.authorPrada López, Isabel
dc.contributor.authorÁlvarez Fernández, Maximiliano
dc.contributor.authorAmaral, Barbas
dc.contributor.authorCasares de Cal, María Ángeles
dc.contributor.authorTomás Carmona, Inmaculada
dc.date.accessioned2020-05-01T14:41:14Z
dc.date.available2020-05-01T14:41:14Z
dc.date.issued2015
dc.identifier.citationBarbosa M, Prada-López I, Álvarez M, Amaral B, de los Angeles C-D-CM, Tomás I (2015) Post-Tooth Extraction Bacteraemia: A Randomized Clinical Trial on the Efficacy of Chlorhexidine Prophylaxis. PLoS ONE 10(5): e0124249. https://doi.org/10.1371/journal.pone.0124249
dc.identifier.urihttp://hdl.handle.net/10347/21970
dc.description.abstractObjectives: To investigate the development of post-extraction bacteraemia (PEB) after the prophylactic use of chlorhexidine (CHX). Patients and Methods: A total of 201 patients who underwent a tooth extraction were randomly distributed into four groups: 52 received no prophylaxis (CONTROL), 50 did a mouthwash with 0.2% CHX before the tooth extraction (CHX-MW), 51 did a mouthwash with 0.2% CHX and a subgingival irrigation with 1% CHX (CHX-MW/SUB_IR) and 48 did a mouthwash with 0.2% CHX and a continuous supragingival irrigation with 1% CHX (CHX-MW/SUPRA_IR). Peripheral venous blood samples were collected at baseline, 30 seconds after performing the mouthwash and the subgingival or supragingival irrigation, and at 30 seconds and 15 minutes after completion of the tooth extraction. Blood samples were analysed applying conventional microbiological cultures under aerobic and anaerobic conditions performing bacterial identification of the isolates. Results: The prevalences of PEB in the CONTROL, CHX-MW, CHX-MW/SUB_IR and CHX-MWSUPRA_IR groups were 52%, 50%, 55% and 50%, respectively, at 30 seconds and 23%, 4%, 10% and 27%, respectively, at 15 minutes. The prevalence of PEB at 15 minutes was significantly higher in the CONTROL group than in the CHX-MW group (23% versus 4%; p = 0.005). At the same time, no differences were found between CONTROL group and CHX-MW/SUB_IR or CHX-MW/SUPRA_IR groups. Streptococci (mostly viridans group streptococci) were the most frequently identified bacteria (69–79%). Conclusions: Performing a 0.2% CHX mouthwash significantly reduces the duration of PEB. Subgingival irrigation with 1% CHX didn’t increase the efficacy of the mouthwash while supragingival irrigation even decreased this efficacy, probably due to the influence of these maneuvers on the onset of bacteraemia. Clinical Relevance: These results confirm the suitability of performing a mouthwash with 0.2% CHX before tooth extractions in order to reduce the duration of PEB. This practice should perhaps be extended to all dental manipulations
dc.description.sponsorshipThis work was supported by project PI11/01383 from Carlos III Institute of Health (General Division of Evaluation and Research Promotion, Madrid, Spain), which is integrated in National Plan of Research, Development and Innovation (PN I+D+I 2008–2011)
dc.language.isoeng
dc.publisherPLOS
dc.rights© 2015 Barbosa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titlePost-tooth extraction bacteraemia: a randomized clinical trial on the efficacy of chlorhexidine prophylaxis
dc.typejournal article
dc.identifier.doi10.1371/journal.pone.0124249
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0124249
dc.type.hasVersionVoR
dc.identifier.essn1932-6203
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
dc.description.peerreviewedSI


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© 2015 Barbosa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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 © 2015 Barbosa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited





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