Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/22064
Ficheiros no ítem
Metadatos do ítem
Título: | Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model |
Autor/a: | Permuy Mendaña, María Guede, David López Peña, Mónica Muñoz Guzón, Fernando María Caeiro Rey, José Ramón González Cantalapiedra, Antonio |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Anatomía, Produción Animal e Ciencias Clínicas Veterinarias |
Palabras chave: | Bone | Cartilage | Diacerein | Osteoarthritis | Rabbit mode | Synovial membrane | |
Data: | 2015 |
Editor: | BioMed Central |
Cita bibliográfica: | Permuy, M., Guede, D., López-Peña, M. et al. Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model. BMC Vet Res 11, 143 (2015). https://doi.org/10.1186/s12917-015-0458-x |
Resumo: | Background: Osteoarthritis is thought to be the most prevalent chronic and disabling joint disease in animals and humans. At present, there is no ideal treatment option. The aim of this study was to assess the effects of the treatment with oral diacerein on articular cartilage, synovial membrane and subchondral bone in an experimental rabbit model of osteoarthritis by micro-CT evaluation and histological analysis. To this purpose, osteoarthritis was surgically induced on one knee of 16 rabbits using the contralateral knee as healthy controls. Treatment was started three weeks later and lasted eight weeks. Animals were divided into two groups for treatment: Placebo (treated daily with oral saline) and diacerein (treated orally with 1.5 mg/kg/day of diacerein). Results: Sample analysis revealed that this model induced osteoarthritis in the operated knee joint. Osteoarthritis placebo group showed a significant increase in non-calcified cartilage thickness and volume with respect to the control placebo group and important changes in the synovial membrane; whereas the parameters measured in subchondral bone remained unchanged. In the osteoarthritis diacerein-treated group the results showed an improvement with respect to the OA placebo group in all parameters, although the results were not statistically significant. Conclusion: The results of this animal study suggested that the diacerein treatment for OA may be able to ameliorate the swelling and surface alterations of the cartilage and exert an anti-inflammatory effect on the synovial membrane, which might contribute to OA improvement, as well as an anabolic effect on subchondral trabecular bone. |
Versión do editor: | https://doi.org/10.1186/s12917-015-0458-x |
URI: | http://hdl.handle.net/10347/22064 |
DOI: | 10.1186/s12917-015-0458-x |
ISSN: | 1746-6148 |
Dereitos: | © 2015 Permuy et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Coleccións
-
- APA-Artigos [117]
A licenza do ítem descríbese como
© 2015 Permuy et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
© 2015 Permuy et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.