Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo
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Título: | Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo |
Autor/a: | Matić, Ivana Z. Đorđić, Marija Grozdanić, Nađa Damjanović, Ana Kolundžija, Branka Erić Nikolić, Aleksandra Džodić, Radan Šašić, Miomir Nikolić, Srđan Dobrosavljević, Danijela Rašković, Sanvila Andrejević, Slađana Gavrilović, Dušica Cordero Santamaría, Óscar Javier Juranić, Zorica D. |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Molecular |
Palabras chave: | CD26 expression | DPPIV serum activity | Melanoma | Vitiligo | |
Data: | 2012 |
Editor: | BMC |
Cita bibliográfica: | Matić, I. Z., Đorđić, M., Grozdanić, N., Damjanović, A., Kolundžija, B., Erić-Nikolić, A., ... & Rašković, S. (2012). Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo. BMC immunology, 13(1), 48. |
Resumo: | Background: Dipeptidyl peptidase IV, a multifunctional serine protease, is implicated in regulation of malignant transformation, promotion and further progression of cancer, exerting tumor-suppressing or even completely opposite - tumor-promoting activities. The aim of present research was to determine the serum DPPIV activity, as well as the percentages of CD26+ lymphocytes, CD26+ overall white blood cells and the mean fluorescence intensity of CD26 expression on lymphocytes in patients with melanoma, people with vitiligo and in healthy controls. Methods: The activity of DPPIV in serum was determined by colorimetric test. Expression of DPPIV (as CD26) on immunocompetent peripheral white blood cells was done using flow cytometry analysis. Results: Data from our study show for the first time statistically significant decrease: in the serum DPPIV activity, in the percentage of CD26+ overall white blood cells and in the percentage of lymphocytes in patients with melanoma in comparison to healthy control people. In addition, significantly lower serum DPPIV activity was found in the group of patients with melanoma in relation to people with vitiligo too. Conclusion: This study indicates the need for exploring the cause and the importance of the disturbances in the serum DPPIV activity and in the CD26 expression on immunocompetent cells in complex molecular mechanisms underlying the development and progression of melanoma |
Versión do editor: | https://doi.org/10.1186/1471-2172-13-48 |
URI: | http://hdl.handle.net/10347/22081 |
DOI: | 10.1186/1471-2172-13-48 |
E-ISSN: | 1471-2172 |
Dereitos: | © 2012 Matić et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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© 2012 Matić et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
© 2012 Matić et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.