Hyperthermia in human ischemic and hemorrhagic stroke: similar outcome, different mechanisms
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/22166
Ficheiros no ítem
Metadatos do ítem
Título: | Hyperthermia in human ischemic and hemorrhagic stroke: similar outcome, different mechanisms |
Autor/a: | Campos Pérez, Francisco Sobrino Moreiras, Tomás Vieites Prado, Alba Pérez Mato, María Rodríguez Yáñez, Manuel Blanco González, Miguel Castillo Sánchez, José Antonio |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina |
Data: | 2013 |
Editor: | PLOS |
Cita bibliográfica: | Campos F, Sobrino T, Vieites-Prado A, Pérez-Mato M, Rodríguez-Yáñez M, Blanco M, et al. (2013) Hyperthermia in Human Ischemic and Hemorrhagic Stroke: Similar Outcome, Different Mechanisms. PLoS ONE 8(11): e78429. https://doi.org/10.1371/journal.pone.0078429 |
Resumo: | Hyperthermia is a predictor of poor outcome in ischemic (IS) and intracerebral hemorrhagic (ICH) stroke. Our aim was to study the plausible mechanisms involved in the poor outcome associated to hyperthermia in stroke. We conducted a case-control study including patients with IS (n = 100) and ICH (n = 100) within the first 12 hours from symptom onset. Specifically, IS and ICH patients were consecutively included into 2 subgroups, according to the highest body temperature within the first 24 hours: Tmax <37.5°C and Tmax ≥37.5°C, up to reach 50 patients per subgroup of temperature for both IS and ICH patients. Body temperature was determined at admission and every 4 hours during the first 48 hours. Main outcome variable was poor functional outcome (modified Rankin scale score >2) at 3 months. Serum levels of glutamate and active MMP-9 were measured at admission. Our results showed that Tmax ≥37.5°C within the first 24 hours was independently associated with poor outcome in both IS (OR, 12.43; 95% CI, 3.73–41.48; p<0.0001) and ICH (OR, 4.29; 95% CI, 1.32–13.91; p = 0.015) after adjusting for variables with a proven biological relevance for outcome. However, when molecular markers levels were included in the logistic regression model, we observed that glutamate (OR, 1.01; 95% CI, 1.00–1.02; p = 0.001) and infarct volume (OR, 1.06; 95% CI, 1.01–1.10; p = 0.015) were the only variables independently associated to poor outcome in IS, and active MMP-9 (OR, 1.04; 95% CI, 1.00–1.08; p = 0.002) and National Institute of Health Stroke Scale (NIHSS) at admission (OR, 1.29; 95% CI, 1.13–1.49; p<0.0001) in ICH. In conclusion, these results suggest that although the outcome associated to hyperthermia is similar in human IS and ICH, the underlying mechanisms may be different. |
Versión do editor: | https://doi.org/10.1371/journal.pone.0078429 |
URI: | http://hdl.handle.net/10347/22166 |
DOI: | 10.1371/journal.pone.0078429 |
E-ISSN: | 1932-6203 |
Dereitos: | © 2013 Campos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
Coleccións
-
- PRSP-Artigos [373]