Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index
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|Title:||Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index
|Author:||Pardo Pérez, María
Crujeiras Martínez, Ana Belén
Amil Diz, María
Jiménez Murcia, Susana
Baños, Rosa M.
Torre, Rafael de la
Fagundo, Ana Beatriz
Fernández Real, Jose M.
Fernández García, José C.
Gómez Ambrosi, Javier
Tinahones Madueño, Francisco José
Fernández Aranda, Fernando
Casanueva Freijo, Felipe
|Affiliation:||Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina
|Date of Issue:||2014
|Citation:||Pardo, M., Crujeiras, A., Amil, M., Aguera, Z., Jiménez-Murcia, S., & Baños, R. et al. (2014). Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index. International Journal Of Endocrinology, 2014, 1-9. https://doi.org/10.1155/2014/857270
|Abstract:||FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.|
|Rights:||Copyright © 2014 María Pardo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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Except where otherwise noted, this item's license is described as Copyright © 2014 María Pardo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited