Residues of anilinopyrimidine fungicides and suspected metabolites in wine samples
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Title: | Residues of anilinopyrimidine fungicides and suspected metabolites in wine samples |
Author: | Castro Varela, Gabriela Pérez Mayán, Leticia Carpinteiro Botana, María Inmaculada Ramil Criado, María Cela Torrijos, Rafael Rodríguez Pereiro, Isaac |
Affiliation: | Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía Universidade de Santiago de Compostela. Instituto de Investigación e Análises Alimentarias |
Subject: | Wine | Pyrimethanil | Cyprodinil | Metabolites | Liquid chromatography-mass spectrometry | |
Date of Issue: | 2020 |
Publisher: | Elsevier |
Citation: | G. Castro, L. Pérez-Mayán and I. Carpinteiro et al., Residues of anilinopyrimidine fungicides and suspected metabolites in wine samples, Journal of Chromatography A, https://doi.org/10.1016/j.chroma.2020.461104 |
Abstract: | The coexistence of the anilinopyrimidine fungicides pyrimethanil (PYR) and cyprodinil (CYP), and suspected metabolites in wine samples was investigated by liquid chromatography (LC) with tandem mass spectrometry (MS/MS), based on triple quadrupole (QqQ) and quadrupole time-of-flight (QTOF) MS instruments. For the first time, quantitative data obtained after solid-phase extraction (SPE) of wine samples have demonstrated the systematic presence of 4-hydroxyanilino derivatives of PYR and CYP in wines containing residues of parent fungicides, at concentrations from 0.2 to 58 ng mL−1. Higher concentration ratios (hydroxylated derivative/active fungicide) were measured in red than in white wines, particularly in case of PYR. On average, the concentrations of PYR-4OH were twice those measured for PYR in red wines. A targeted search of hydroxyl derivatives in wine extracts by LC-QTOF-MS showed the existence of additional hydroxylation positions in the pyrimidine ring and/or in the alkyl substituents bond to this cycle in the structure of both anti-botrytis fungicides. Moreover, free and glycosylated forms of the hydroxylated metabolites for both fungicides coexist in wine samples. In case of CYP, it is proved that hydroxylated and glycosylated metabolites are already present in grapes before vinification |
Publisher version: | https://doi.org/10.1016/j.chroma.2020.461104 |
URI: | http://hdl.handle.net/10347/22365 |
DOI: | 10.1016/j.chroma.2020.461104 |
ISSN: | 0021-9673 |
Rights: | © 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NCND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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