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dc.contributor.authorCastro Varela, Gabriela
dc.contributor.authorPérez Mayán, Leticia
dc.contributor.authorCarpinteiro Botana, María Inmaculada
dc.contributor.authorRamil Criado, María
dc.contributor.authorCela Torrijos, Rafael
dc.contributor.authorRodríguez Pereiro, Isaac
dc.date.accessioned2020-05-15T19:07:05Z
dc.date.available2022-04-28T01:00:08Z
dc.date.issued2020
dc.identifier.citationG. Castro, L. Pérez-Mayán and I. Carpinteiro et al., Residues of anilinopyrimidine fungicides and suspected metabolites in wine samples, Journal of Chromatography A, https://doi.org/10.1016/j.chroma.2020.461104
dc.identifier.issn0021-9673
dc.identifier.urihttp://hdl.handle.net/10347/22365
dc.description.abstractThe coexistence of the anilinopyrimidine fungicides pyrimethanil (PYR) and cyprodinil (CYP), and suspected metabolites in wine samples was investigated by liquid chromatography (LC) with tandem mass spectrometry (MS/MS), based on triple quadrupole (QqQ) and quadrupole time-of-flight (QTOF) MS instruments. For the first time, quantitative data obtained after solid-phase extraction (SPE) of wine samples have demonstrated the systematic presence of 4-hydroxyanilino derivatives of PYR and CYP in wines containing residues of parent fungicides, at concentrations from 0.2 to 58 ng mL−1. Higher concentration ratios (hydroxylated derivative/active fungicide) were measured in red than in white wines, particularly in case of PYR. On average, the concentrations of PYR-4OH were twice those measured for PYR in red wines. A targeted search of hydroxyl derivatives in wine extracts by LC-QTOF-MS showed the existence of additional hydroxylation positions in the pyrimidine ring and/or in the alkyl substituents bond to this cycle in the structure of both anti-botrytis fungicides. Moreover, free and glycosylated forms of the hydroxylated metabolites for both fungicides coexist in wine samples. In case of CYP, it is proved that hydroxylated and glycosylated metabolites are already present in grapes before vinification
dc.description.sponsorshipL.P.M acknowledges a FPU grant to the Spanish Ministry of Science. The study was supported by Xunta de Galicia, Spanish Government and EU funds through grants GRC-ED431C 2017/36, PGC2018-094613-B-I00 and the Interreg SUDOE VINOVERT project
dc.language.isoeng
dc.publisherElsevier
dc.rights© 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NCND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectWine
dc.subjectPyrimethanil
dc.subjectCyprodinil
dc.subjectMetabolites
dc.subjectLiquid chromatography-mass spectrometry
dc.titleResidues of anilinopyrimidine fungicides and suspected metabolites in wine samples
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1016/j.chroma.2020.461104
dc.relation.publisherversionhttps://doi.org/10.1016/j.chroma.2020.461104
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía
dc.contributor.affiliationUniversidade de Santiago de Compostela. Instituto de Investigación e Análises Alimentarias
dc.description.peerreviewedSI


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© 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NCND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Except where otherwise noted, this item's license is described as  © 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NCND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)





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