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dc.contributor.authorVázquez Tato, María del Pilar
dc.contributor.authorMena Menéndez, Alberto
dc.contributor.authorFeás Sánchez, Xesús
dc.contributor.authorSeijas Vázquez, Julio Antonio
dc.date.accessioned2020-05-19T15:46:33Z
dc.date.available2020-05-19T15:46:33Z
dc.date.issued2014
dc.identifier.citationVázquez Tato, M.P., Mena Menéndez, A., Feás Sánchez, X. y Seijas Vázquez, J.A. (2014). Novel microwave- assisted synthesis of the immunomodulator organotellurium compound ammonium trichloro( dioxoethylene- O, O') tellurate ( AS101). Int.J.Mol.Sci., vol. 15, 3287-3298
dc.identifier.urihttp://hdl.handle.net/10347/22426
dc.description.abstractAmmonium trichloro[1,2-ethanediolato-O,O']-tellurate (AS101) is the most important synthetic Te compound from the standpoint of its biological activity. It is a potent immunomodulator with a variety of potential therapeutic applications and antitumoral action in several preclinical and clinical studies. An experimental design has been used to develop and optimize a novel microwave-assisted synthesis (MAOS) of the AS101. In comparison to the results observed in the literature, refluxing Te(IV) chloride and ethylene glycol in acetonitrile (Method A), or by refluxing Te(IV) chloride and ammonium chloride in ethylene glycol (Method B), it was found that the developed methods in the present work are an effective alternative, because although performance slightly decreases compared to conventional procedures (75% vs. 79% by Method A, and 45% vs. 51% by Method B), reaction times decreased from 4 h to 30 min and from 4 h to 10 min, by Methods A and B respectively. MAOS is proving to be of value in the rapid synthesis of compounds with new and improved biological activities, specially based on the benefit of its shorter reaction times
dc.description.sponsorshipWe acknowledge XUNTA DE GALICIA for financial support: Grants INCITE09 262346PR and PGIDIT06RAG26103PR. X.F. would also like to thank the Xunta de Galicia (Isidro Parga Pondal Program for young researchers, Grant No. IPP-020)
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectTellurium
dc.subjectAS101
dc.subjectAmmonium trichloro[1,2-ethanediolato-O,O']-tellurate
dc.subjectMicrowave irradiation
dc.subjectAntitumoral
dc.titleNovel microwave-assisted synthesis of the immunomodulator organotellurium compound ammonium trichloro( dioxoethylene- O, O') tellurate ( AS101)
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/ijms15023287
dc.relation.publisherversionhttps://doi.org/10.3390/ijms15023287
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1422-0067
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
Except where otherwise noted, this item's license is described as  © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)





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