Show simple item record

dc.contributor.authorAmin, Surriya
dc.contributor.authorUllah, Barkat
dc.contributor.authorAli, Mumtaz
dc.contributor.authorRauf, Abdur
dc.contributor.authorKhan, Haroon
dc.contributor.authorUriarte Villares, Eugenio
dc.contributor.authorSobarzo Sánchez, Eduardo Marcelo
dc.date.accessioned2020-05-20T13:41:44Z
dc.date.available2020-05-20T13:41:44Z
dc.date.issued2019
dc.identifier.citationAmin, S.; Ullah, B.; Ali, M.; Rauf, A.; Khan, H.; Uriarte, E.; Sobarzo-Sánchez, E. (2019). Potent in vitro α-glucosidase inhibition of secondary metabolites derived from dryopteris cycadina. Molecules 24(3), 427; doi: 10.3390/molecules24030427
dc.identifier.urihttp://hdl.handle.net/10347/22471
dc.description.abstractα-glucosidase is responsible for the hydrolysis of complex carbohydrates into simple absorbable glucose and causes postprandial hyperglycemia. α-glucosidase inhibition is thus the ideal target to prevent postprandial hyperglycemia. The present study was therefore designed to analyze the effects of various compounds isolated from Dryopteris cycadina against α-glucosidase including β-Sitosterol 1, β-Sitosterol3-O-β-D-glucopyranoside 2, 3, 5, 7-trihydroxy-2-(p-tolyl) chorman-4-one 3, Quercetin-3-0-β-D-glucopyranoside (3/→0-3///)- β-D- Quercetin -3-0- β –D-galactopyranoside 4 and 5, 7, 4/ -Trihydroxyflavon-3-glucopyranoid 5. The in vitro spectrophotometric method was used for the analysis of test compounds against possible inhibition. Similarly, molecular docking studies were performed using the MOE software. These compounds showed concentration-dependent inhibition on α-glucosidase, and compounds 1 (IC50: 143 ± 0.47 µM), 3 (IC50:133 ± 6.90 µM) and 5 (IC50: 146 ± 1.93 µM) were more potent than the standard drug, acarbose (IC50: 290 ± 0.54 µM). Computational studies of these compounds strongly supported the in vitro studies and showed strong binding receptor sensitivity. In short, the secondary metabolites isolated from D. cycadina demonstrated potent α-glucosidase inhibition that were supported by molecular docking with a high docking score
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2019 by the authors. Open Access. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDryopteris cycadina
dc.subjectIsolated compounds
dc.subjectα-glucosidase inhibition
dc.subjectMolecular docking
dc.titlePotent in vitro α-glucosidase inhibition of secondary metabolites derived from dryopteris cycadina
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/molecules24030427
dc.relation.publisherversionhttps://doi.org/10.3390/molecules24030427
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1420-3049
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Facultade de Farmacia
dc.description.peerreviewedSI


Files in this item

application/pdf
Name: 2019_molecules_amin_potent.pdf
Size: 2.914 Mb
Format: PDF


Thumbnail

This item appears in the following Collection(s)

Show simple item record

© 2019 by the authors. Open Access. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's license is described as  © 2019 by the authors. Open Access. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





Harvesters:Useful links:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback