Low-dosage antibiotic intake can disturb gut microbiota in mice
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Título: | Low-dosage antibiotic intake can disturb gut microbiota in mice |
Outro/s título/s: | La ingesta de bajas dosis de antibióticos es capaz de alterar la microbiota intestinal en ratones |
Autor/a: | Roca Saavedra, Paula Rodríguez, José A. Lamas Freire, Alexandre Miranda López, José Manuel Nebot García, Carolina Graciela Cardelle Cobas, Alejandra Franco Abuín, Carlos Manuel Cepeda Sáez, Alberto |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía |
Palabras chave: | Gut microbiota | Antibiotics | Mice | Firmicutes | Proteobacteria | Lactobacillus | Bifidobacterium | Microbiota intestinal | Antibióticos | Ratón | Firmicutes | Proteobacteria | Lactobacillus | Bifidobacterium | |
Data: | 2018 |
Editor: | Taylor & Francis |
Cita bibliográfica: | Paula Roca-Saavedra, Jose A. Rodriguez, Alexandre Lamas, Jose Manuel Miranda, Carolina Nebot, Alejandra Cardelle-Cobas, Carlos M. Franco & Alberto Cepeda (2018) Low-dosage antibiotic intake can disturb gut microbiota in mice, CyTA - Journal of Food, 16:1, 672-678, DOI: 10.1080/19476337.2018.1474264 |
Resumo: | The proportion of different microbial populations in gut microbiota (GM) is an important factor that in recent years has been linked to obesity and numerous metabolic diseases. Antibiotics are one of the factors that can dramatically alter GM at therapeutic dosages, but their effects at subtherapeutic doses have been less investigated. Here, a mouse model using a total of 60 C57BL/6J mice was used to compare the evolution of total microbiota, four phyla and two genera considered as probiotics in control mice, and mice exposed to 50 µg/kg of ampicillin, 100 µg/kg of tetracycline or 100 µg/kg of sulphadiazine. The results obtained found that the presence of antibiotics in foods, even at trace concentrations, can disturb mouse GM, causing in all antibiotics significant increases of Proteobacteria (about 2 log CFU/g) or decreases of Bifidobacterium and Lactobacillus (about 1 log CFU/g) for the cases of ampicillin and sulphadiazine. La composición de las diferentes poblaciones microbianas presentes en la microbiota intestinal humana es un aspecto importante que en los últimos años ha sido relacionada tanto con la obesidad con como muchas patologías metabólicas. Los antibióticos son uno de los agentes que pueden alterar de manera radical la composición de la microbiota intestinal cuando se utilizan a dosis terapéuticas, pero sus efectos a dosis sub-terapéuticas han sido menos investigados. Para este fin, se ha realizado un ensayo empleando 60 ratones C57BL/6J para comparar la evolución de la microbiota total, así como 4 filos y 2 géneros bacterianos beneficiosos en ratones control, ratones expuestos a 50 µg/kg de ampicilina, ratones expuestos a 100 µg/kg de tetraciclina y ratones expuestos a 100 µg/kg de sulfadiacina. Los resultados obtenidos mostraron que la presencia de antibióticos en los alimentos, incluso a concentraciones traza, pueden alterar la microbiota intestinal de los ratones, causando todos los antibióticos un incremento significativo de Proteobacteria (aproximadamente 2 log ufc/g), o descensos en los géneros Bifidobacterium y Lactobacillus (aproximadamente 1 log ufc/g) en los casos de la ampicilina y la sulfadiacina. |
Versión do editor: | https://doi.org/10.1080/19476337.2018.1474264 |
URI: | http://hdl.handle.net/10347/22501 |
DOI: | 10.1080/19476337.2018.1474264 |
ISSN: | 1947-6337 |
E-ISSN: | 1947-6345 |
Dereitos: | © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.