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dc.contributor.authorRoca Saavedra, Paula
dc.contributor.authorRodríguez, José A.
dc.contributor.authorLamas Freire, Alexandre
dc.contributor.authorMiranda López, José Manuel
dc.contributor.authorNebot García, Carolina
dc.contributor.authorCardelle Cobas, Alejandra
dc.contributor.authorFranco Abuín, Carlos Manuel
dc.contributor.authorCepeda Sáez, Alberto
dc.date.accessioned2020-05-20T19:11:07Z
dc.date.available2020-05-20T19:11:07Z
dc.date.issued2018
dc.identifier.citationPaula Roca-Saavedra, Jose A. Rodriguez, Alexandre Lamas, Jose Manuel Miranda, Carolina Nebot, Alejandra Cardelle-Cobas, Carlos M. Franco & Alberto Cepeda (2018) Low-dosage antibiotic intake can disturb gut microbiota in mice, CyTA - Journal of Food, 16:1, 672-678, DOI: 10.1080/19476337.2018.1474264
dc.identifier.issn1947-6337
dc.identifier.urihttp://hdl.handle.net/10347/22501
dc.description.abstractThe proportion of different microbial populations in gut microbiota (GM) is an important factor that in recent years has been linked to obesity and numerous metabolic diseases. Antibiotics are one of the factors that can dramatically alter GM at therapeutic dosages, but their effects at subtherapeutic doses have been less investigated. Here, a mouse model using a total of 60 C57BL/6J mice was used to compare the evolution of total microbiota, four phyla and two genera considered as probiotics in control mice, and mice exposed to 50 µg/kg of ampicillin, 100 µg/kg of tetracycline or 100 µg/kg of sulphadiazine. The results obtained found that the presence of antibiotics in foods, even at trace concentrations, can disturb mouse GM, causing in all antibiotics significant increases of Proteobacteria (about 2 log CFU/g) or decreases of Bifidobacterium and Lactobacillus (about 1 log CFU/g) for the cases of ampicillin and sulphadiazine.
dc.description.abstractLa composición de las diferentes poblaciones microbianas presentes en la microbiota intestinal humana es un aspecto importante que en los últimos años ha sido relacionada tanto con la obesidad con como muchas patologías metabólicas. Los antibióticos son uno de los agentes que pueden alterar de manera radical la composición de la microbiota intestinal cuando se utilizan a dosis terapéuticas, pero sus efectos a dosis sub-terapéuticas han sido menos investigados. Para este fin, se ha realizado un ensayo empleando 60 ratones C57BL/6J para comparar la evolución de la microbiota total, así como 4 filos y 2 géneros bacterianos beneficiosos en ratones control, ratones expuestos a 50 µg/kg de ampicilina, ratones expuestos a 100 µg/kg de tetraciclina y ratones expuestos a 100 µg/kg de sulfadiacina. Los resultados obtenidos mostraron que la presencia de antibióticos en los alimentos, incluso a concentraciones traza, pueden alterar la microbiota intestinal de los ratones, causando todos los antibióticos un incremento significativo de Proteobacteria (aproximadamente 2 log ufc/g), o descensos en los géneros Bifidobacterium y Lactobacillus (aproximadamente 1 log ufc/g) en los casos de la ampicilina y la sulfadiacina.
dc.description.sponsorshipThe authors want to thank the European Regional Development Funds (FEDER): [Grant Number GRC 2014/004] for covering the costs
dc.language.isoeng
dc.publisherTaylor & Francis
dc.rights© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectGut microbiota
dc.subjectAntibiotics
dc.subjectMice
dc.subjectFirmicutes
dc.subjectProteobacteria
dc.subjectLactobacillus
dc.subjectBifidobacterium
dc.subjectMicrobiota intestinal
dc.subjectAntibióticos
dc.subjectRatón
dc.subjectFirmicutes
dc.subjectProteobacteria
dc.subjectLactobacillus
dc.subjectBifidobacterium
dc.titleLow-dosage antibiotic intake can disturb gut microbiota in mice
dc.title.alternativeLa ingesta de bajas dosis de antibióticos es capaz de alterar la microbiota intestinal en ratones
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1080/19476337.2018.1474264
dc.relation.publisherversionhttps://doi.org/10.1080/19476337.2018.1474264
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1947-6345
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía
dc.description.peerreviewedSI


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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
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 © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.





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