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dc.contributor.authorCorrea Jaraba, Kenia Shaily
dc.contributor.authorLindín Novo, Mónica
dc.contributor.authorDíaz Fernández, Fernando
dc.date.accessioned2020-05-24T18:18:38Z
dc.date.available2020-05-24T18:18:38Z
dc.date.issued2018
dc.identifier.citationCorrea-Jaraba KS, Lindín M and Díaz F (2018) Increased Amplitude of the P3a ERP Component as a Neurocognitive Marker for Differentiating Amnestic Subtypes of Mild Cognitive Impairment. Front. Aging Neurosci. 10:19
dc.identifier.urihttp://hdl.handle.net/10347/22507
dc.description.abstractThe event-related potential (ERP) technique has been shown to be useful for evaluating changes in brain electrical activity associated with different cognitive processes, particularly in Alzheimer’s disease (AD). Longitudinal studies have shown that a high proportion of people with amnestic mild cognitive impairment (aMCI) go on to develop AD. aMCI is divided into two subtypes according to the presence of memory impairment only (single-domain aMCI: sdaMCI) or impairment of memory and other cognitive domains (multi-domain aMCI: mdaMCI). The main aim of this study was to examine the effects of sdaMCI and mdaMCI on the P3a ERP component associated with the involuntary orientation of attention toward unattended infrequent novel auditory stimuli. Participants performed an auditory-visual distraction-attention task, in which they were asked to ignore the auditory stimuli (standard, deviant, and novel) and to attend to the visual stimuli (responding to some of them: Go stimuli). P3a was identified in the Novel minus Standard difference waveforms, and reaction times (RTs) and hits (in response to Go stimuli) were also analyzed. Participants were classified into three groups: Control, 20 adults (mean age (M): 65.8 years); sdaMCI, 19 adults (M: 67 years); and mdaMCI, 11 adults (M: 71 years). In all groups, the RTs were significantly longer when Go stimuli were preceded by novel (relative to standard) auditory stimuli, suggesting a distraction effect triggered by novel stimuli; mdaMCI participants made significantly fewer hits than control and sdaMCI participants. P3a comprised two consecutive phases in all groups: early-P3a (e-P3a), which may reflect the orienting response toward the irrelevant stimuli, and late-P3a (l-P3a), which may be a correlate of subsequent evaluation of these stimuli. The e-P3a amplitude was significantly larger in mdaMCI than in sdaMCI participants, and the l-P3a amplitude was significantly larger in mdaMCI than in sdaMCI and Control participants, indicating greater involuntary capture of attention to unattended novel auditory stimuli and allocation of more attentional resources for the subsequent evaluation of these stimuli in mdaMCI participants. The e-P3a and l-P3a components showed moderate to high sensitivity and specificity for distinguishing between groups, suggesting that both may represent optimal neurocognitive markers for differentiating aMCI subtypes
dc.description.sponsorshipThis study was supported by grants from the Spanish Government (Ministerio de Economía y Competitividad) (PSI2014-55316-C3-3-R) and from the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC; ED431-2017/27), with FEDER funds
dc.language.isoeng
dc.publisherFrontiers Media
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2014-55316-C3-3-R/ES/EVOLUCION DEL DETERIORO COGNITIVO EN EL ENVEJECIMIENTO NORMAL, DCL Y EA: ESTUDIO LONGITUDINAL CON MARCADORES PSICOFISIOLOGICOS Y DE NEUROIMAGEN FUNCIONAL
dc.rightsCopyright © 2018 Correa-Jaraba, Lindín and Díaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAmnestic mild cognitive impairment (aMCI)
dc.subjectAlzheimer’s disease (AD)
dc.subjectBiomarkers
dc.subjectEvent-related potentials (ERPs)
dc.subjectP3a
dc.subjectInvoluntary attention
dc.titleIncreased Amplitude of the P3a ERP Component as a Neurocognitive Marker for Differentiating Amnestic Subtypes of Mild Cognitive Impairment
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3389/fnagi.2018.00019
dc.relation.publisherversionhttps://doi.org/10.3389/fnagi.2018.00019
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1663-4365
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e Psicobioloxía
dc.description.peerreviewedSI


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Copyright © 2018 Correa-Jaraba, Lindín and Díaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
Except where otherwise noted, this item's license is described as  Copyright © 2018 Correa-Jaraba, Lindín and Díaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms





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