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dc.contributor.author | Dhiman, Priyanka |
dc.contributor.author | Malik, Neelam |
dc.contributor.author | Sobarzo Sánchez, Eduardo Marcelo |
dc.contributor.author | Uriarte Villares, Eugenio |
dc.contributor.author | Khatkar, Anurag |
dc.date.accessioned | 2020-05-25T15:04:51Z |
dc.date.available | 2020-05-25T15:04:51Z |
dc.date.issued | 2019 |
dc.identifier.citation | Dhiman, P., Malik, N., Sobarzo-Sánchez, E., Uriarte, E., Khatkar, A. (2019). Quercetin and related chromenone derivatives as monoamine oxidase inhibitors: targeting neurological and mental disorders. Molecules 24(3), 418; doi: 10.3390/molecules24030418 |
dc.identifier.uri | http://hdl.handle.net/10347/22549 |
dc.description.abstract | Monoamine oxidase inhibitions are considered as important targets for the treatment of depression, anxiety, and neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. This has encouraged many medicinal chemistry research groups for the development of most promising selective monoamine oxidase (MAO) inhibitors. A large number of plant isolates also reported for significant MAO inhibition potential in recent years. Differently substituted flavonoids have been prepared and investigated as MAO-A and MAO-B inhibitors. Flavonoid scaffold showed notable antidepressant and neuroprotective properties as revealed by various and established preclinical trials. The current review made an attempt to summarizing and critically evaluating the new findings on the quercetin and related flavonoid derivatives functions as potent MAO isoform inhibitors |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.rights | © 2019 by the authors. Open Access. Licensee MDPI, Basel, Switzerland. This article is an open Access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.subject | Monoamine oxidase |
dc.subject | Neurodegenerative disorder |
dc.subject | Mental disorders |
dc.subject | Quercetin |
dc.subject | Flavonoids |
dc.subject | Monoamine oxidase inhibitors |
dc.subject | In-silico design |
dc.title | Quercetin and related chromenone derivatives as monoamine oxidase inhibitors: targeting neurological and mental disorders |
dc.type | journal article |
dc.identifier.doi | 10.3390/molecules24030418 |
dc.relation.publisherversion | https://doi.org/10.3390/molecules24030418 |
dc.type.hasVersion | VoR |
dc.identifier.essn | 1420-3049 |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Facultade de Farmacia |
dc.description.peerreviewed | SI |
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