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dc.contributor.authorDhiman, Priyanka
dc.contributor.authorMalik, Neelam
dc.contributor.authorSobarzo Sánchez, Eduardo Marcelo
dc.contributor.authorUriarte Villares, Eugenio
dc.contributor.authorKhatkar, Anurag
dc.date.accessioned2020-05-25T15:04:51Z
dc.date.available2020-05-25T15:04:51Z
dc.date.issued2019
dc.identifier.citationDhiman, P., Malik, N., Sobarzo-Sánchez, E., Uriarte, E., Khatkar, A. (2019). Quercetin and related chromenone derivatives as monoamine oxidase inhibitors: targeting neurological and mental disorders. Molecules 24(3), 418; doi: 10.3390/molecules24030418
dc.identifier.urihttp://hdl.handle.net/10347/22549
dc.description.abstractMonoamine oxidase inhibitions are considered as important targets for the treatment of depression, anxiety, and neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. This has encouraged many medicinal chemistry research groups for the development of most promising selective monoamine oxidase (MAO) inhibitors. A large number of plant isolates also reported for significant MAO inhibition potential in recent years. Differently substituted flavonoids have been prepared and investigated as MAO-A and MAO-B inhibitors. Flavonoid scaffold showed notable antidepressant and neuroprotective properties as revealed by various and established preclinical trials. The current review made an attempt to summarizing and critically evaluating the new findings on the quercetin and related flavonoid derivatives functions as potent MAO isoform inhibitors
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2019 by the authors. Open Access. Licensee MDPI, Basel, Switzerland. This article is an open Access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMonoamine oxidase
dc.subjectNeurodegenerative disorder
dc.subjectMental disorders
dc.subjectQuercetin
dc.subjectFlavonoids
dc.subjectMonoamine oxidase inhibitors
dc.subjectIn-silico design
dc.titleQuercetin and related chromenone derivatives as monoamine oxidase inhibitors: targeting neurological and mental disorders
dc.typejournal article
dc.identifier.doi10.3390/molecules24030418
dc.relation.publisherversionhttps://doi.org/10.3390/molecules24030418
dc.type.hasVersionVoR
dc.identifier.essn1420-3049
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Facultade de Farmacia
dc.description.peerreviewedSI


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© 2019 by the authors. Open Access. Licensee MDPI, Basel, Switzerland. This article is an open Access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
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 © 2019 by the authors. Open Access. Licensee MDPI, Basel, Switzerland. This article is an open Access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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