Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin
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Título: | Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin
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Autor/a: | Garrido Novelle, Marta
Vázquez Villar, María Jesús
Martinello, Kátia da Boit
Sánchez Garrido, Miguel A.
Tena Sempere, Manuel
Diéguez González, Carlos
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Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Departamento de Fisioloxía
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Palabras chave: | Developmental biology | Feeding behaviour | |
Data: | 2015
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Editor: | Nature Publishing Group
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Cita bibliográfica: | Novelle, M., Vázquez, M., Martinello, K. et al. Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin. Sci Rep 4, 4855 (2015). https://doi.org/10.1038/srep04855
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Resumo: | It is currently accepted that ambient, non-genetic factors influence perinatal development and evoke structural and functional changes that may persist throughout life. Overfeeding and androgenization after birth are two of these key factors that could result in “metabolic imprinting” of neuronal circuits early in life and, thereby, increase the body weight homeostatic “set point”, stimulate appetite and result in obesity. Our aim was to determine the influence of these obesogenic factors on the response to ghrelin. We observed the expected orexigenic effect of ghrelin regardless of the nutritional or hormonal manipulations to which the animals were subjected to at early postnatal development and this effect remained intact at later stages of development. In fact, ghrelin responses increased significantly when the animals were subjected to one of the two manipulations, but not when both were combined. An increased response to ghrelin could explain the obese phenotype displayed by individuals with modified perinatal environment. |
Versión do editor: | https://doi.org/10.1038/srep04855 |
URI: | http://hdl.handle.net/10347/23053
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DOI: | 10.1038/srep04855 |
E-ISSN: | 2045-2322
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Dereitos: | © 2014 The Author(s). This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
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