Show simple item record

dc.contributor.authorGuerrero López, Ana
dc.contributor.authorIglesias García, Cristina
dc.contributor.authorRaguz, Selina
dc.contributor.authorFloridia, Ebel
dc.contributor.authorGil, Jesús
dc.contributor.authorPombo Ramos, Celia María
dc.contributor.authorZalvide Torrente, Juan Bautista
dc.date.accessioned2020-06-29T10:37:20Z
dc.date.available2020-06-29T10:37:20Z
dc.date.issued2015
dc.identifier.citationGuerrero, A., Iglesias, C., Raguz, S., Floridia, E., Gil, J., Pombo, C.M. and Zalvide, J. (2015), The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell, 14: 274-283. doi:10.1111/acel.12316
dc.identifier.issn1474-9718
dc.identifier.urihttp://hdl.handle.net/10347/23069
dc.description.abstractMutations in cerebral cavernous malformation 3 gene are knownto result in development of vascular malformations and haverecently been proposed to also give rise to meningiomas. Wereport in this study that lack of CCM3 unexpectedly impairs thesenescence response of cells, and this is related to the inability ofCCM3-deficient cells to induce the C/EBPb transcription factor andimplement the senescence-associated secretory phenotype.Induction of C/EBPb and cytokines is also impaired in the absenceof CCM3 in response to cytokines in nonsenescent cells, pointingto it being a primary defect and not secondary to impairedsenescence. CCM3-deficient cells also have a defect in autophagyat late passages of culture, and this defect is also not dependenton impaired senescence, as it is evident in immortal cells afternutrient starvation. Further, these two defects may be related, asenforcing autophagy in CCM3-deficient late passage cellsincreases C/EBPb cytokine expression. These results broaden ourknowledge on the mechanisms by which CCM3 deficiency resultsin disease and open new avenues of research into both CCM3 andsenescence biology
dc.description.sponsorshipThis work was supported by Xunta de Galicia grant INCITE 09 208 110 PR GCP2013‐032 (to C. M. P.), and Ministerio de Ciencia e Innovación grant SAF2011‐24940 (to J. Z.), cofinanced with Regional Development European Funds, and ERANET neuron PRI‐PIMNEU‐2011‐1337. A.G. was recipient of an FPU predoctoral fellowship from Ministerio de Ciencia e Innovación, Spain. C.I. and E.F. are recipients of a predoctoral fellowship from Xunta de Galicia, Spain
dc.language.isoeng
dc.publisherWiley
dc.rights© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAutophagy
dc.subjectCEBPb
dc.subjectPDCD10
dc.subjectSASP
dc.titleThe cerebral cavernous malformation 3 gene is necessary for senescence induction
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1111/acel.12316
dc.relation.publisherversionhttps://doi.org/10.1111/acel.12316
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1474-9726
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxía
dc.description.peerreviewedSI


Files in this item

application/pdf
Name: 2015_agingcell_guerrero_cerebral.pdf
Size: 1.444 Mb
Format: PDF


Thumbnail

This item appears in the following Collection(s)

Show simple item record

© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
This item's license is described as
 © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited





Harvesters:Interesting links:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback