Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptor
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| Title: | Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptor |
| Author: | Learte Aymamí, Soraya Rodríguez Villar, Jéssica Vázquez Sentís, Marco Eugenio Mascareñas Cid, José Luis |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Subject: | Chemical biology | DNA binding | Molecular recognition | Peptides | Supramolecular chemistry | |
| Date of Issue: | 2020 |
| Publisher: | Wiley |
| Citation: | S. Learte-Aymamí, J. Rodríguez, M. E. Vázquez, J. L. Mascareñas, Chem. Eur. J. 2020 , 26 , 8875. |
| Abstract: | The nickel(II)‐mediated self‐assembly of a multimeric DNA binder is described. The binder is composed of two metal‐chelating peptides derived from a bZIP transcription factor (brHis2) and one short AT‐hook domain equipped with two bipyridine ligands (HkBpy2). These peptides reversibly assemble in the presence of NiII ions at selected DNA sequences of 13 base pairs |
| Publisher version: | https://doi.org/10.1002/chem.202001277 |
| URI: | http://hdl.handle.net/10347/23208 |
| DOI: | 10.1002/chem.202001277 |
| ISSN: | 0947-6539 |
| E-ISSN: | 1521-3765 |
| Rights: | © 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions |
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