Show simple item record

dc.contributor.authorCajaraville Leiro, Ana
dc.contributor.authorSuárez Rivero, Jaime
dc.contributor.authorLópez Estévez, Susana
dc.contributor.authorVarela Carrete, Jesús Ángel
dc.contributor.authorSaá Rodríguez, Carlos
dc.date.accessioned2020-10-05T06:50:01Z
dc.date.available2020-10-05T06:50:01Z
dc.date.issued2015
dc.identifier.citationCajaraville, A., Suárez, J., López, S., Varela. J. A., Saá, C. (2015). Rh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted 1,4‐ Dihydroquinazolin‐2‐amines. Chem. Commun., 51, 82, 15157-15160
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/10347/23348
dc.descriptionNOTICE: This is the peer reviewed version of the following article: Cajaraville, A., Suárez, J., López, S., Varela. J. A., Saá, C. (2015). Rh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted 1,4‐ Dihydroquinazolin‐2‐amines. Chem. Commun., 51, 82, 15157-15160. [doi: 10.1039/C5CC06388D]. This article may be used for non-commercial purposes in accordance with The Royal Society of Chemistry Terms and Conditions for self-archiving
dc.description.abstractA novel and mild RhIII-catalyzed [5+1] oxidative cycloaddition between arylguanidines and alkynes efficiently affords C4-disubstituted 1,4-dihydroquinazolin-2-amines. Members of this family of heterocycles, which contain the relevant cyclic guanidine units, have shown interesting pharmacological properties. The mechanism probably involves the formation of an eight-membered rhodacycle in which the imine unit of guanidine is coordinated to the Rh center. This rhodacycle would evolve to give the C-4 disubstituted 1,4-dihydroquinazolin-2-amine skeleton.
dc.description.sponsorshipThis work was supported by MICINN (project CTQ2011‐28258), Xunta de Galicia and European Regional Development Fund (projects GRC2014/032 and EM 2012/051). A. C. and J. S. thank Spanish MICINN and Xunta de Galicia for a predoctoral FPI fellowship and postdoctoral contract, respectively
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.rights© The Royal Society of Chemistry 2015. This article may be used for non-commercial purposes in accordance with The Royal Society of Chemistry Terms and Conditions for self-archiving
dc.subjectAlkynes
dc.subjectArylguanidines
dc.subjectCyclization
dc.subjectDihydroquinazolinamines
dc.subjectRhodium
dc.titleRh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted 1,4‐ Dihydroquinazolin‐2‐amines
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1039/C5CC06388D
dc.relation.publisherversionhttps://doi.org/10.1039/C5CC06388D
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1364-548X
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


Files in this item

application/pdf
Name: Chem. Commun. 2015, 51, 15157-15160.pdf
Size: 377.9 Kb
Format: PDF


Thumbnail

This item appears in the following Collection(s)

Show simple item record






Harvesters:Useful links:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback