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dc.contributor.authorMiguel Ávila, Joan
dc.contributor.authorTomás Gamasa, María
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2020-10-05T12:51:35Z
dc.date.available2021-07-06T01:00:08Z
dc.date.issued2020
dc.identifier.citationJ. Miguel-Ávila, M. Tomás-Gamasa, J. L. Mascareñas, Angew. Chem. Int. Ed. 2020, 59, 17628
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/10347/23368
dc.descriptionThis is the peer reviewed version of the following article: J. Miguel-Ávila, M. Tomás-Gamasa, J. L. Mascareñas, Angew. Chem. Int. Ed. 2020, 59, 17628, which has been published in final form at https://doi.org/10.1002/anie.202006689. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
dc.description.abstractMetal‐mediated intracellular reactions are becoming invaluable tools in chemical and cell biology, and hold promise for strongly impacting the field of biomedicine. Most of the reactions reported so far involve either uncaging or redox processes. Demonstrated here for the first time is the viability of performing multicomponent alkyne cycloaromatizations inside live mammalian cells using ruthenium catalysts. Both fully intramolecular and intermolecular cycloadditions of diynes with alkynes are feasible, the latter providing an intracellular synthesis of appealing anthraquinones. The power of the approach is further demonstrated by generating anthraquinone AIEgens (AIE=aggregation induced emission) that otherwise do not go inside cells, and by modifying the intracellular distribution of the products by simply varying the type of ruthenium complex
dc.description.sponsorshipThis work has received financial support from the Spanish Government (SAF2016‐76689‐R, ORFEO‐CINQA network CTQ2016‐81797‐REDC) the Consellería de Cultura, Educación e Ordenación Universitaria (2015‐CP082, ED431C‐2017/19 and Centro Singular de Investigación de Galicia Accreditation 2019–2022, ED431G 2019/03), the European Union (European Regional Development Fund‐ERDF corresponding to the multiannual financial framework 2014–2020), and the European Research Council (Advanced Grant No. 340055). J.M.Á. thanks the Ministerio de Educación, Cultura y Deporte for the FPU fellowship (FPU16/00711) and M.T.G. thanks the financial support from the Agencia Estatal de Investigación (RTI2018‐093813‐J‐I00)
dc.language.isoeng
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016‐76689‐R/ES
dc.rights© 2020 Wiley-VCH GmbH. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
dc.subjectAlkynes
dc.subjectBiological chemistry
dc.subjectCycloadditions
dc.subjectIntracellular chemistry
dc.subjectRuthenium
dc.titleIntracellular Ruthenium‐Promoted (2+2+2) Cycloadditions
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1002/anie.202006689
dc.relation.publisherversionhttps://doi.org/10.1002/anie.202006689
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1521-3773
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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