Surface-Enhanced Raman Scattering Detection of Nucleic Acids Exhibiting Sterically Accessible Guanines Using Ruthenium-Polypyridyl Reagents
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Título: | Surface-Enhanced Raman Scattering Detection of Nucleic Acids Exhibiting Sterically Accessible Guanines Using Ruthenium-Polypyridyl Reagents |
Autor/a: | Martínez Calvo, Miguel Guerrini, Luca Rodríguez Villar, Jéssica Álvarez Puebla, Ramón A. Mascareñas Cid, José Luis |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Palabras chave: | Ruthenium | Nucleic acids | Genetics | Raman spectroscopy | Guanine | |
Data: | 2020 |
Editor: | American Chemical Society |
Cita bibliográfica: | J. Phys. Chem. Lett. 2020, 11, 17, 7218–7223 |
Resumo: | Here, we report the application of surface-enhanced Raman scattering (SERS) spectroscopy as a rapid and practical tool for assessing the formation of coordinative adducts between nucleic acid guanines and ruthenium polypyridyl reagents. The technology provides a practical approach for the wash-free and quick identification of nucleic acid structures exhibiting sterically accessible guanines. This is demonstrated for the detection of a quadruplex-forming sequence present in the promoter region of the c-myc oncogene, which exhibits a nonpaired, reactive guanine at a flanking position of the G-quartets |
Descrición: | This is the peer reviewed version of the following article: Martínez-Calvo, M.; Guerrini,
L.; Rodríguez, J.; Álvarez Puebla, R. A.; Mascareñas, J. L. (2020), Surface-enhanced Raman
Scattering Detection of Nucleic Acids exhibiting Sterically Accessible Guanines using
Ruthenium-polypyridyl Reagents. J. Phys. Chem. Lett., 11: 7218–7223, which has been
published in final form at https://doi.org/10.1021/acs.jpclett.0c02148. This article may be
used for non-commercial purposes in accordance with ACS Terms and Conditions for Use
of Self-Archived Versions |
Versión do editor: | https://doi.org/10.1021/acs.jpclett.0c02148 |
URI: | http://hdl.handle.net/10347/23369 |
DOI: | 10.1021/acs.jpclett.0c02148 |
E-ISSN: | 1948-7185 |
Dereitos: | Copyright © 2020 American Chemical Society. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archiving |
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