dc.contributor.author | Fais, Antonella |
dc.contributor.author | Corda, Marcella |
dc.contributor.author | Era, Benedetta |
dc.contributor.author | Fadda, M. Benedetta |
dc.contributor.author | Matos, Maria João Correia Pinto Carvalho de |
dc.contributor.author | Quezada González, Elías Neftalí |
dc.contributor.author | Santana Penín, María Lourdes |
dc.contributor.author | Picciau, Carmen |
dc.contributor.author | Podda, Gianni |
dc.contributor.author | Delogu, Giovanna Lucia |
dc.date.accessioned | 2020-10-21T13:17:46Z |
dc.date.available | 2020-10-21T13:17:46Z |
dc.date.issued | 2009 |
dc.identifier.citation | Fais, A.; Corda, M.; Era, B.; Fadda, M.B.; Matos, M.J.; Quezada q, E.; Santana, L.; Picciau, C.; Podda, G.; Delogu, G. Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids. Molecules 2009, 14, 2514-2520. |
dc.identifier.uri | http://hdl.handle.net/10347/23392 |
dc.description.abstract | In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3’,4’,5’-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition |
dc.description.sponsorship | We thank Progetto di Ricerca Scientifica 2007-Università di Cagliari and Fondazione del Banco di Sardegna, Xunta de Galicia (PGIDIT05PXIB20304PR) and Ministerio de Sanidad y Consumo (FIS PI061537 and PI061457) for financial support |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.rights | © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/) |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ |
dc.subject | Tyrosinase inhibitors |
dc.subject | Resveratrol |
dc.subject | Coumarins |
dc.title | Tyrosinase inhibitor activity of coumarin-resveratrol hybrids |
dc.type | info:eu-repo/semantics/article |
dc.identifier.DOI | 10.3390/molecules14072514 |
dc.relation.publisherversion | https://doi.org/10.3390/molecules14072514 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.identifier.e-issn | 1420-3049 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
dc.description.peerreviewed | SI |
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Except where otherwise noted, this item's license is described as © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)