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dc.contributor.authorFais, Antonella
dc.contributor.authorCorda, Marcella
dc.contributor.authorEra, Benedetta
dc.contributor.authorFadda, M. Benedetta
dc.contributor.authorMatos, Maria João Correia Pinto Carvalho de
dc.contributor.authorQuezada González, Elías Neftalí
dc.contributor.authorSantana Penín, María Lourdes
dc.contributor.authorPicciau, Carmen
dc.contributor.authorPodda, Gianni
dc.contributor.authorDelogu, Giovanna Lucia
dc.date.accessioned2020-10-21T13:17:46Z
dc.date.available2020-10-21T13:17:46Z
dc.date.issued2009
dc.identifier.citationFais, A.; Corda, M.; Era, B.; Fadda, M.B.; Matos, M.J.; Quezada q, E.; Santana, L.; Picciau, C.; Podda, G.; Delogu, G. Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids. Molecules 2009, 14, 2514-2520.
dc.identifier.urihttp://hdl.handle.net/10347/23392
dc.description.abstractIn the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3’,4’,5’-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition
dc.description.sponsorshipWe thank Progetto di Ricerca Scientifica 2007-Università di Cagliari and Fondazione del Banco di Sardegna, Xunta de Galicia (PGIDIT05PXIB20304PR) and Ministerio de Sanidad y Consumo (FIS PI061537 and PI061457) for financial support
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectTyrosinase inhibitors
dc.subjectResveratrol
dc.subjectCoumarins
dc.titleTyrosinase inhibitor activity of coumarin-resveratrol hybrids
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/molecules14072514
dc.relation.publisherversionhttps://doi.org/10.3390/molecules14072514
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1420-3049
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
Except where otherwise noted, this item's license is described as  © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)




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