A ‘click chemistry’ approach to the straightforward synthesis of new 4-aryl-1,2,3-triazolocarbanucleosides
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Título: | A ‘click chemistry’ approach to the straightforward synthesis of new 4-aryl-1,2,3-triazolocarbanucleosides |
Autor/a: | Pérez Castro, Isabel Caamaño Santos, María Olga Fernández González, Franco García, Marcos D. López Santamaría, María del Carmen Clercq, Erik de |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Química Orgánica Universidade de Santiago de Compostela. Facultade de Farmacia |
Palabras chave: | Click chemistry | Triazoles | Carbanucleosides | Antiviral | Ribavirin | |
Data: | 2010 |
Editor: | Arkat USA Inc |
Cita bibliográfica: | Pérez-Castro, Isabel, Caamaño, Olga, Fernández, Franco, García, Marcos D., López, Carmen, Clercq, Eirik D. A ‘click chemistry’ approach to the straightforward synthesis of new 4-aryl-1,2,3-triazolocarbanucleosides . ARKIVOC 2010 p. 152-168 |
Resumo: | The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3- triazolyl carbanucleosides of type (±)-10/(±)-11 related to the broad spectrum antiviral agent ribavirin 1 are described. These compounds were produced using a “click chemistry” strategy starting from readily available protected alcohol 13b. The synthetic approach made use of olefinbased organic reactions for the stereoselective construction of the appropriately functionalized cyclopentane ring moiety followed by copper (I) catalyzed Huisgen 1,3-dipolar cycloaddition of azides and alkynes for the regioselective construction of the heterocyclic triazole moiety |
Versión do editor: | http://dx.doi.org/10.3998/ark.5550190.0011.314 |
URI: | http://hdl.handle.net/10347/23463 |
DOI: | 10.3998/ark.5550190.0011.314 |
ISSN: | 1551-7012 |
E-ISSN: | 1551-7004 |
Dereitos: | © 2010 The Author(s). This is an open access article published by ARKIVOC under a Creative Commons Attribution-NonCommercial 3.0 License |
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