Some Guidelines for the Synthesis and Melting Characterization of Azide Poly(ethylene glycol) Derivatives
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Title: | Some Guidelines for the Synthesis and Melting Characterization of Azide Poly(ethylene glycol) Derivatives |
Author: | González Fernández, Daniel Torneiro Abuín, Mercedes Lazzari, Massimo |
Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Física Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Subject: | Poly(ethylene glycol) | PEGylation | Nanoparticles | Functionalization | Azide-terminated | Melting behavior | |
Date of Issue: | 2020 |
Publisher: | MDPI |
Citation: | González-Fernández, D.; Torneiro, M.; Lazzari, M. Some Guidelines for the Synthesis and Melting Characterization of Azide Poly(ethylene glycol) Derivatives. Polymers 2020, 12, 1269 |
Abstract: | We provide fundamental guidelines in the form of a tutorial to be taken into account for the preparation and characterization of a specific class of poly(ethylene glycol) (PEG) derivatives, namely azide-terminated PEGs. Special attention is given to the effect of these chain end groups and their precursors on properties affecting the PEGylation of proteins, nanoparticles and nanostructured surfaces. Notwithstanding the presence of 13C satellite peaks, we show that 1H NMR enables not only the routine quantitative determination of chain-end substitution, but is also a unique method to calculate the absolute number average molecular weight of PEG derivatives. In the use of size exclusion chromatography to get molecular weight distributions, we highlight the importance of distinguishing between eventual secondary reactions involving molecular weight changes and the formation of PEG complexes due to residual amounts of metal cations from reactants. Finally, we show that azide end groups affect PEG melting behavior. In contrast to oxygen-containing end groups, azides do not interact with PEG segments, thus inducing defect formation in the crystal lattice and the reduction of crystal sizes. Melting temperature and degree of crystallinity decrease become especially relevant for PEGs with very low molecular weight, and its comprehension is particularly important for solid-state applications |
Publisher version: | https://doi.org/10.3390/polym12061269 |
URI: | http://hdl.handle.net/10347/23582 |
DOI: | 10.3390/polym12061269 |
E-ISSN: | 2073-4360 |
Rights: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Atribución 4.0 Internacional |
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Except where otherwise noted, this item's license is described as © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)