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dc.contributor.authorFernández Ferreiro, Sara
dc.contributor.authorCarrera González, María Cristina
dc.contributor.authorVilariño del Río, Natalia
dc.contributor.authorLouzao Ojeda, María Carmen
dc.contributor.authorSantamarina Pernas, Germán
dc.contributor.authorGonzález Cantalapiedra, Antonio
dc.contributor.authorBotana López, Luis Miguel
dc.date.accessioned2020-11-06T11:52:08Z
dc.date.available2020-11-06T11:52:08Z
dc.date.issued2015
dc.identifier.citationFerreiro, S.F.; Carrera, C.; Vilariño, N.; Louzao, M.C.; Santamarina, G.; Cantalapiedra, A.G.; Botana, L.M. Acute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX. Toxins 2015, 7, 1030-1047
dc.identifier.urihttp://hdl.handle.net/10347/23591
dc.description.abstractPhycotoxins are marine toxins produced by phytoplankton that can get accumulated in filter feeding shellfish. Human intoxication episodes occur due to contaminated seafood consumption. Okadaic acid (OA) and dynophysistoxins (DTXs) are phycotoxins responsible for a severe gastrointestinal syndrome called diarrheic shellfish poisoning (DSP). Yessotoxins (YTXs) are marine toxins initially included in the DSP class but currently classified as a separated group. Food safety authorities from several countries have regulated the content of DSPs and YTXs in shellfish to protect human health. In mice, OA and YTX have been associated with ultrastructural heart damage in vivo. Therefore, this study explored the potential of OA, DTX-1 and YTX to cause acute heart toxicity. Cardiotoxicity was evaluated in vitro by measuring hERG (human èter-a-go-go gene) channel activity and in vivo using electrocardiogram (ECG) recordings and cardiac damage biomarkers. The results demonstrated that these toxins do not exert acute effects on hERG channel activity. Additionally, in vivo experiments showed that these compounds do not alter cardiac biomarkers and ECG in rats acutely. Despite the ultrastructural damage to the heart reported for these toxins, no acute alterations of heart function have been detected in vivo, suggesting a functional compensation in the short term
dc.description.sponsorshipThe research leading to these results has received funding from the following FEDER cofunded-grants. From CDTI and Technological Funds, supported by Ministerio de Economía y Competitividad, AGL2012-40185-CO2-01 and Consellería de Cultura, Educación e Ordenación Universitaria, GRC2013-016, and through Axencia Galega de Innovación, Spain, ITC-20133020 SINTOX, IN852A 2013/16-3 MYTIGAL. From CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD. From the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency (FP7/2007–2013) under grant agreement Nos. 265409 µAQUA, 315285 CIGUATOOLS and 312184 PHARMASEA
dc.language.isoeng
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/265409
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/315285
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/312184
dc.rights© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/)
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectOkadaic acid
dc.subjectDynophysistoxins
dc.subjectYessotoxin
dc.subjectCardiotoxicity
dc.subjecthERG
dc.subjectECG
dc.subjectCardiac biomarkers
dc.titleAcute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/toxins7041030
dc.relation.publisherversionhttps://doi.org/10.3390/toxins7041030
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn2072-6651
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Ciencias Clínicas Veterinarias
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía
dc.description.peerreviewedSI


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© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's license is described as  © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/)





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