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dc.contributor.authorRubiolo Gaytán, Juan Andrés
dc.contributor.authorTernon, Eva
dc.contributor.authorLópez Alonso, Henar
dc.contributor.authorThomas, Olivier P.
dc.contributor.authorVega Lisi, Félix Víctor
dc.contributor.authorRodríguez Vieytes, María Mercedes
dc.contributor.authorBotana López, Luis Miguel
dc.date.accessioned2020-11-09T08:44:34Z
dc.date.available2020-11-09T08:44:34Z
dc.date.issued2013
dc.identifier.citationRubiolo, J.A.; Ternon, E.; López-Alonso, H.; Thomas, O.P.; Vega, F.V.; Vieytes, M.R.; Botana, L.M. Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae. Mar. Drugs 2013, 11, 4419-4434
dc.identifier.urihttp://hdl.handle.net/10347/23606
dc.description.abstractIn this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of this yeast. The compound induced cell cycle arrest in G2/M followed by an increase in cell DNA content and size. When the type of cell death was analyzed, we observed that crambescidin-816 induced apoptosis. The antifungal effect indicates that crambescidins, and mostly crambescidin-816, could serve as a lead compound to fight fungal infections
dc.description.sponsorshipThe research leading to these results has received funding from the following FEDER cofunded-grants: From Ministerio de Ciencia y Tecnología, Spain: AGL2009-13581-CO2-01, AGL2012-40485-CO2-01. From Xunta de Galicia, Spain: 10PXIB261254 PR. From the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency (FP7/2007-2013) under grant agreement Nos. 211326—CP (CONffIDENCE), 265896 BAMMBO, 265409 µAQUA, and 262649 BEADS, 315285 Ciguatools and 312184 PharmaSea. From the Atlantic Area Programme (Interreg IVB Trans-national): 2009-1/117 Pharmatlantic
dc.language.isoeng
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/265896
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/265409
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/262649
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/315285
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/312184
dc.relationinfo:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/AGL2009-13581-C02-01/ES/Evaluacion De Los Riesgos De Salud Publica Debidos A Toxinas Marinas De Aguas Templadas En Las Costas Europeas Y Del Efecto Sinergico Con Otras Toxinas Habituales En Estas Latitudes. Subproyecto 2
dc.rights© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectCrambescidine-816
dc.subjectAntifungal
dc.subjectCell cycle arrest
dc.subjectApoptosis
dc.titleCrambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/md11114419
dc.relation.publisherversionhttps://doi.org/10.3390/md11114419
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1660-3397
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxía
dc.description.peerreviewedSI


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© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
Except where otherwise noted, this item's license is described as  © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)





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