Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer
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Título: | Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer |
Autor/a: | Fernández Campos, Francisco Navarro, Francesc Corrales, Adrian Picas, Jordi Pena, Eloy González, Jordi Otero Espinar, Francisco Javier |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
Palabras chave: | Nail lacquers | Cyclodextrins | Methylsulfonylmethane | Active penetration | Biotin | |
Data: | 2020 |
Editor: | MDPI |
Cita bibliográfica: | Fernández-Campos, F.; Navarro, F.; Corrales, A.; Picas, J.; Pena, E.; González, J.; Otero-Espinar, F.J. Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer. Pharmaceutics 2020, 12, 730 |
Resumo: | A new cyclodextrin polypseudorotaxanes nail lacquer (Regenail®) containing biotin, methyl sulphonyl methane (MSM), and dimethylsilanediol salicylate was developed and evaluated in vitro and in vivo. The product was developed to improve nail status and diminish signs of pathological nail alterations. A reference product (Betalfatrus®) was used for comparative purposes. An in vitro permeation experiment in hooves showed high MSM and biotin absorption. The content of sulfur and silicon in hooves was also found to be higher compared with the reference product. MSM was tested in human keratinocytes, exhibiting a good cytotoxicity profile and anti-inflammatory activity by the reduction in IL-8 and TNF-α under LPS stimuli. A clinical study was performed to check product safety and efficacy against nail brittleness and alterations such as Beau’s lines and onychorrhexis. A reduction in both alterations and in surface roughness without alteration of nail structure was observed, with a good level of patient acceptance and satisfaction |
Versión do editor: | https://doi.org/10.3390/pharmaceutics12080730 |
URI: | http://hdl.handle.net/10347/23615 |
DOI: | 10.3390/pharmaceutics12080730 |
E-ISSN: | 1999-4923 |
Dereitos: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Atribución 4.0 Internacional |
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