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dc.contributor.authorFernández Campos, Francisco
dc.contributor.authorNavarro, Francesc
dc.contributor.authorCorrales, Adrian
dc.contributor.authorPicas, Jordi
dc.contributor.authorPena, Eloy
dc.contributor.authorGonzález, Jordi
dc.contributor.authorOtero Espinar, Francisco Javier
dc.date.accessioned2020-11-09T09:42:40Z
dc.date.available2020-11-09T09:42:40Z
dc.date.issued2020
dc.identifier.citationFernández-Campos, F.; Navarro, F.; Corrales, A.; Picas, J.; Pena, E.; González, J.; Otero-Espinar, F.J. Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer. Pharmaceutics 2020, 12, 730
dc.identifier.urihttp://hdl.handle.net/10347/23615
dc.description.abstractA new cyclodextrin polypseudorotaxanes nail lacquer (Regenail®) containing biotin, methyl sulphonyl methane (MSM), and dimethylsilanediol salicylate was developed and evaluated in vitro and in vivo. The product was developed to improve nail status and diminish signs of pathological nail alterations. A reference product (Betalfatrus®) was used for comparative purposes. An in vitro permeation experiment in hooves showed high MSM and biotin absorption. The content of sulfur and silicon in hooves was also found to be higher compared with the reference product. MSM was tested in human keratinocytes, exhibiting a good cytotoxicity profile and anti-inflammatory activity by the reduction in IL-8 and TNF-α under LPS stimuli. A clinical study was performed to check product safety and efficacy against nail brittleness and alterations such as Beau’s lines and onychorrhexis. A reduction in both alterations and in surface roughness without alteration of nail structure was observed, with a good level of patient acceptance and satisfaction
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNail lacquers
dc.subjectCyclodextrins
dc.subjectMethylsulfonylmethane
dc.subjectActive penetration
dc.subjectBiotin
dc.titleTransungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/pharmaceutics12080730
dc.relation.publisherversionhttps://doi.org/10.3390/pharmaceutics12080730
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1999-4923
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.description.peerreviewedSI


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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's license is described as  © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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