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dc.contributor.authorDonato, Cristina di
dc.contributor.authorIacovino, Rosa
dc.contributor.authorIsernia, Carla
dc.contributor.authorMalgieri, Gaetano
dc.contributor.authorVarela García, Ángela
dc.contributor.authorConcheiro Nine, Ángel Joaquín
dc.contributor.authorÁlvarez Lorenzo, Carmen Isabel
dc.date.accessioned2020-11-10T11:08:15Z
dc.date.available2020-11-10T11:08:15Z
dc.date.issued2020
dc.identifier.citationDi Donato, C.; Iacovino, R.; Isernia, C.; Malgieri, G.; Varela-Garcia, A.; Concheiro, A.; Alvarez-Lorenzo, C. Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir. Nanomaterials 2020, 10, 613
dc.identifier.urihttp://hdl.handle.net/10347/23635
dc.description.abstractAcyclovir (ACV) is one of the most used antiviral drugs for the treatment of herpes simplex virus infections and other relevant mucosal infections caused by viruses. Nevertheless, the low water solubility of ACV limits both its bioavailability and antiviral performance. The combination of block copolymer micelles and cyclodextrins (CDs) may result in polypseudorotaxanes with tunable drug solubilizing and gelling properties. However, the simultaneous addition of various CDs has barely been investigated yet. The aim of this work was to design and characterize ternary combinations of Pluronic® F127 (PF127), αCD and βCD in terms of polypseudorotaxane formation, rheological behavior, and ACV solubilization ability and controlled release. The formation of polypseudorotaxanes between PF127 and the CDs was confirmed by FT-IR spectroscopy, X-ray diffraction, and NMR spectroscopy. The effects of αCD/βCD concentration range (0–7% w/w) on copolymer (6.5% w/w) gel features were evaluated at 20 and 37 °C by rheological studies, resulting in changes of the copolymer gelling properties. PF127 with αCD/βCD improved the solubilization of ACV, maintaining the biocompatibility (hen’s egg test on the chorio-allantoic membrane). In addition, the gels were able to sustain acyclovir delivery. The formulation prepared with similar proportions of αCD and βCD provided a slower and more constant release. The results obtained suggest that the combination of Pluronic with αCD/βCD mixtures can be a valuable approach to tune the rheological features and drug release profiles from these supramolecular gels
dc.description.sponsorshipThis research was funded by MIUR PRIN [20157WZM8A] (Italy), MINECO [SAF2017-83118-R] (Spain), Agencia Estatal de Investigación (AEI, Spain), Xunta de Galicia [ED431C 2016/008; AEMAT ED431E 2018/08] and European Regional Development Fund (FEDER)
dc.language.isoeng
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-83118-R/ES/ARQUITECTURAS POLIMERICAS 3D ACTIVAS PARA MEDICINA REGENERATIVA Y TERAPIA LOCALIZADA
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPluronic® F127
dc.subjectCyclodextrins mixture
dc.subjectAcyclovir
dc.subjectPolypseudorotaxanes
dc.subjectSolubilization
dc.subjectControlled release
dc.titlePolypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/nano10040613
dc.relation.publisherversionhttps://doi.org/10.3390/nano10040613
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn2079-4991
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.description.peerreviewedSI


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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's license is described as  © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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