Desarrollo de Antagonistas selectivos del receptor A3 de Adenosina
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| Title: | Desarrollo de Antagonistas selectivos del receptor A3 de Adenosina |
| Alternative Title: | Development of adenosine A3 receptor selective antagonists |
| Author: | Miranda Pastoriza, Darío |
| Advisor: | Sotelo Pérez, Eddy |
| Affiliation: | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Subject: | Adenosina | Receptor A3 de adenosina | Antagonistas | Reacciones multicomponente | Reacción de Biginelli | Adenosine | A3 antagonist receptor | Antagonists | Multicomponent reaction | Biginelli reaction | |
| Date of Issue: | 2020-11 |
| Abstract: | El presente Trabajo de Fin de Grado describe el diseño, síntesis y evaluación farmacológica de derivados del sistema 1,4-dihidrobenzo[4,5]imidazo[1,2-a]pirimidina como antagonistas del receptor A3 de adenosina. Empleando una variante de la reacción de Biginelli se obtuvo una colección de 19 ligandos. Uno de los compuestos sintetizados mostró una elevada afinidad (Ki=2.28 nM) por el receptor A3 de adenosina The current project describes the design, synthesis and pharmacological evaluation of 1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine derivates as potential antagonists of the A3 adenosine receptor. By employing the Biginelli reaction, a collection of 19 ligands has been obtained. Furthermore, a compound with A3 receptor affinity (Ki=2.28 nM) has been identified |
| Embargo: | 2021-11-18 |
| URI: | http://hdl.handle.net/10347/23733 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Attribution-NonCommercial-NoDerivatives 4.0 Internacional